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Open AccessArticle

Dual-Functionalized Pesticide Nanocapsule Delivery System with Improved Spreading Behavior and Enhanced Bioactivity

Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing 100081, China
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Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2020, 10(2), 220; https://doi.org/10.3390/nano10020220
Received: 6 January 2020 / Revised: 20 January 2020 / Accepted: 23 January 2020 / Published: 27 January 2020
(This article belongs to the Special Issue Nano-Hybrids: Synthesis, Characterization and Applications)
The prevention and control of pests and diseases are becoming increasingly difficult owing to extensive pesticide resistance. The synergistic use of pesticides for disease control is an effective way of slowing pesticide resistance, reducing the number of pesticide applications, and protecting the environment. In this study, a dual-functionalized pesticide nanocapsule delivery system loaded with two active ingredients (AIs)—validamycin and thifluzamide—was developed to prevent and control rice sheath blight; the nanocapsule system was based on a water–oil–water double emulsion method combined with high-pressure homogenization technology. Our results showed that the dual-functionalized pesticide nanocapsules were monodisperse spheres with a mean particle size of ~260 nm and had good storage stability. Compared with commercial formulations, the dual-functionalized pesticide nanocapsules exhibited good foliar spread owing to their small size, which is beneficial for reducing the loss of pesticides on the leaves. The 50% median effect concentration and synergistic ratio against Rhizoctonia solani of the dual-functionalized pesticide nanocapsules and commercial formulation were 0.0082 and 0.0350 μg/mL, and 2.088 and 0.917, respectively. These findings indicate that the bioactivity of the dual-functionalized system was significantly better than that of the commercial formulations and that the dual-functionalized system demonstrated a clear synergistic effect between the two AIs. The system presented here is simple, fast, and capable of dual-pesticide loading with significant synergistic effects. Our findings could help to facilitate the improvement of pesticides efficiency and the slowing of pesticide resistance. View Full-Text
Keywords: validamycin; thifluzamide; dual-functionalized pesticide nanocapsules; storage stability; foliar spread; bioactivity; synergistic effect validamycin; thifluzamide; dual-functionalized pesticide nanocapsules; storage stability; foliar spread; bioactivity; synergistic effect
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MDPI and ACS Style

Cui, J.; Sun, C.; Wang, A.; Wang, Y.; Zhu, H.; Shen, Y.; Li, N.; Zhao, X.; Cui, B.; Wang, C.; Gao, F.; Zeng, Z.; Cui, H. Dual-Functionalized Pesticide Nanocapsule Delivery System with Improved Spreading Behavior and Enhanced Bioactivity. Nanomaterials 2020, 10, 220.

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