Sensitive Voltammetric Sensor for Tryptophan Detection by Using Polyvinylpyrrolidone Functionalized Graphene/GCE

He, Quanguo; Liu, Jun; Feng, Jinxia; Wu, Yiyong; Tian, Yaling; Li, Guangli; Chen, Dongchu

doi:10.3390/nano10010125

Open AccessArticle

Sensitive Voltammetric Sensor for Tryptophan Detection by Using Polyvinylpyrrolidone Functionalized Graphene/GCE

by

Quanguo He

^1,2

,

Jun Liu

^2,*,

Jinxia Feng

²,

Yiyong Wu

²

,

Yaling Tian

²,

Guangli Li

²

and

Dongchu Chen

^1,*

¹

School of Materials Science and Energy Engineering, Foshan University, Foshan 528000, China

²

School of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, China

^*

Authors to whom correspondence should be addressed.

Nanomaterials 2020, 10(1), 125; https://doi.org/10.3390/nano10010125

Submission received: 7 December 2019 / Revised: 26 December 2019 / Accepted: 7 January 2020 / Published: 9 January 2020

(This article belongs to the Special Issue Nano-Hybrids: Synthesis, Characterization and Applications)

Download

Browse Figures

Versions Notes

Abstract

In this paper, an electrochemical method for the measurement of tryptophan (Trp) was developed based on a glassy carbon electrode modified with polyvinylpyrrolidonefunctionalized graphene (PVP-GR)/glassy carbon electrode (GCE). In 0.1 M phosphate buffer solution (PBS, pH = 2.2), compared with bare GCE, PVP/GCE, and GR/GCE, the oxidation peak current of Trp increased dramatically at PVP-GR/GCE. The oxidation mechanism of Trp on the PVP-GR/GCE was discussed and the experimental conditions were optimized. Under the best experimental conditions, the oxidation peak current of Trp was proportional to its concentration in the range of 0.06 µM–10.0 µM and 10.0–100.0 µM, and the limit of detection (LOD) was 0.01 µM (S/N = 3). The target modified electrode with excellent repeatability, stability and selectivity, was successfully applied to detectTrp in drugs and biological samples.

Keywords: polyvinylpyrrolidone; graphene; tryptophan; electrochemical behavior; voltammetric determination

Share and Cite

MDPI and ACS Style

He, Q.; Liu, J.; Feng, J.; Wu, Y.; Tian, Y.; Li, G.; Chen, D. Sensitive Voltammetric Sensor for Tryptophan Detection by Using Polyvinylpyrrolidone Functionalized Graphene/GCE. Nanomaterials 2020, 10, 125. https://doi.org/10.3390/nano10010125

AMA Style

He Q, Liu J, Feng J, Wu Y, Tian Y, Li G, Chen D. Sensitive Voltammetric Sensor for Tryptophan Detection by Using Polyvinylpyrrolidone Functionalized Graphene/GCE. Nanomaterials. 2020; 10(1):125. https://doi.org/10.3390/nano10010125

Chicago/Turabian Style

He, Quanguo, Jun Liu, Jinxia Feng, Yiyong Wu, Yaling Tian, Guangli Li, and Dongchu Chen. 2020. "Sensitive Voltammetric Sensor for Tryptophan Detection by Using Polyvinylpyrrolidone Functionalized Graphene/GCE" Nanomaterials 10, no. 1: 125. https://doi.org/10.3390/nano10010125

APA Style

He, Q., Liu, J., Feng, J., Wu, Y., Tian, Y., Li, G., & Chen, D. (2020). Sensitive Voltammetric Sensor for Tryptophan Detection by Using Polyvinylpyrrolidone Functionalized Graphene/GCE. Nanomaterials, 10(1), 125. https://doi.org/10.3390/nano10010125

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Sensitive Voltammetric Sensor for Tryptophan Detection by Using Polyvinylpyrrolidone Functionalized Graphene/GCE

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI