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Open AccessCommunication

Study of 1D and 2D Carbon Nanomaterial in Alginate Films

1
Biomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, c/Guillem de Castro 94, 46001 Valencia, Spain
2
Escuela Técnica Superior de Arquitectura, Universitat Politècnica de València, Camí de Vera s/n, 46022 Valencia, Spain
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(2), 206; https://doi.org/10.3390/nano10020206
Received: 20 December 2019 / Revised: 20 January 2020 / Accepted: 22 January 2020 / Published: 24 January 2020
Alginate-based materials hold great promise in bioengineering applications such as skin wound healing and scaffolds for tissue engineering. Nevertheless, cell adhesion of mammalian cells on these hydrophilic materials is very poor. In cases such as polycaprolactone, poly(hydroxy-3-butyrate-co-3-valerate) and gelatin, the incorporation of hydrophobic carbon nanofibers (CNFs) and hydrophilic graphene oxide (GO) has shown significant improvement of cell adhesion and proliferation. The incorporation of these carbon nanomaterials (CNMs) into alginate films can enhance their mechanical performance, wettability, water diffusion and antibacterial properties. Herein, we report the effect of adding these CNMs into alginate films on cell adhesion for the first time. Thus, the results of this study showed that these nanocomposites are non-cytotoxic in human keratinocyte HaCaT cells. Nevertheless, contrary to what has been reported for other polymers, cell adhesion on these advanced alginate-based composites was not improved. Therefore, both types of composite films possess similar biological behavior, in terms of cell adhesion and non-cytotoxicity, and enhanced physical and antibacterial properties in comparison to neat alginate for potential biomedical and bioengineering applications. View Full-Text
Keywords: graphene oxide; carbon nanofibers; calcium alginate; films; cytotoxicity; cell adhesion; human keratinocyte HaCaT cells graphene oxide; carbon nanofibers; calcium alginate; films; cytotoxicity; cell adhesion; human keratinocyte HaCaT cells
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Salesa, B.; Llorens-Gámez, M.; Serrano-Aroca, Á. Study of 1D and 2D Carbon Nanomaterial in Alginate Films. Nanomaterials 2020, 10, 206.

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