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Open AccessArticle

Comparison of Different Approaches to Surface Functionalization of Biodegradable Polycaprolactone Scaffolds

1
National University of Science and Technology “MISIS”, Leninsky prospect 4, Moscow 119049, Russia
2
CEITEC—Central European Institute of Technology, Brno University of Technology, Purkyňova 123, 601 90 Brno, Czech Republic
3
Institute of Physical Engineering, Brno University of Technology, Technicka 2896/2, 616 69 Brno, Czech Republic
4
N.N. Blokhin Russian Cancer Research Center, Kashirskoe shosse 24, Moscow 115478, Russia
5
Scientific Institute of Clinical and Experimental Lymphology– Branch of the ICG SB RAS, 2 Timakova str., Novosibirsk 630060, Russia
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(12), 1769; https://doi.org/10.3390/nano9121769
Received: 9 November 2019 / Revised: 6 December 2019 / Accepted: 9 December 2019 / Published: 12 December 2019
Due to their good mechanical stability compared to gelatin, collagen or polyethylene glycol nanofibers and slow degradation rate, biodegradable poly-ε-caprolactone (PCL) nanofibers are promising material as scaffolds for bone and soft-tissue engineering. Here, PCL nanofibers were prepared by the electrospinning method and then subjected to surface functionalization aimed at improving their biocompatibility and bioactivity. For surface modification, two approaches were used: (i) COOH-containing polymer was deposited on the PCL surface using atmospheric pressure plasma copolymerization of CO2 and C2H4, and (ii) PCL nanofibers were coated with multifunctional bioactive nanostructured TiCaPCON film by magnetron sputtering of TiC–CaO–Ti3POx target. To evaluate bone regeneration ability in vitro, the surface-modified PCL nanofibers were immersed in simulated body fluid (SBF, 1×) for 21 days. The results obtained indicate different osteoblastic and epithelial cell response depending on the modification method. The TiCaPCON-coated PCL nanofibers exhibited enhanced adhesion and proliferation of MC3T3-E1 cells, promoted the formation of Ca-based mineralized layer in SBF and, therefore, can be considered as promising material for bone tissue regeneration. The PCL–COOH nanofibers demonstrated improved adhesion and proliferation of IAR-2 cells, which shows their high potential for skin reparation and wound dressing. View Full-Text
Keywords: tissue engineering; polycaprolactone nanofibers; plasma modification; mineralization; XPS tissue engineering; polycaprolactone nanofibers; plasma modification; mineralization; XPS
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MDPI and ACS Style

Permyakova, E.S.; Kiryukhantsev-Korneev, P.V.; Gudz, K.Y.; Konopatsky, A.S.; Polčak, J.; Zhitnyak, I.Y.; Gloushankova, N.A.; Shtansky, D.V.; Manakhov, A.M. Comparison of Different Approaches to Surface Functionalization of Biodegradable Polycaprolactone Scaffolds. Nanomaterials 2019, 9, 1769.

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