Magnetite-Arginine Nanoparticles as a Multifunctional Biomedical Tool
1
Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, Am Mühlenberg 1, 14476 Potsdam, Germany
2
Laboratoire “Matière et Systèmes Complexes” (MSC), UMR 7057 CNRS, Université Paris 7 Diderot, 75205 Paris CEDEX 13, France
3
Section of Experimental Oncoclogy and Nanomedicine (SEON), ENT Department, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glückstraße 10a, 91054 Erlangen, Germany
4
Department of Anesthesiology, Kurume University Hospital, Cognitive and MolecularResearch Institute of Brain Diseases, Kurume University, 65-1, Asahimachi, Kurume 830-0011, Japan
5
Bundesanstalt für Materialforschung und -prüfung, Unter den Eichen 87, 12205 Berlin, Germany
6
nanoPET Pharma GmbH, Luisencarrée Robert-Koch-Platz 4, 10115 Berlin, Germany
7
Institute of Biomedical Engineering and Informatics, Technische Universität Ilmenau, PF 100565, 98684 Ilmenau, Germany
8
Aix-Marseille Université, CEA, CNRS, BIAM, 13108 Saint Paul lez Durance, France
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(10), 2014; https://doi.org/10.3390/nano10102014
Received: 5 August 2020
/
Revised: 1 October 2020
/
Accepted: 2 October 2020
/
Published: 13 October 2020
(This article belongs to the Special Issue Functional Nanomagnetics and Magneto-Optical Nanomaterials)
Iron oxide nanoparticles are a promising platform for biomedical applications, both in terms of diagnostics and therapeutics. In addition, arginine-rich polypeptides are known to penetrate across cell membranes. Here, we thus introduce a system based on magnetite nanoparticles and the polypeptide poly-l-arginine (polyR-Fe3O4). We show that the hybrid nanoparticles exhibit a low cytotoxicity that is comparable to Resovist®, a commercially available drug. PolyR-Fe3O4 particles perform very well in diagnostic applications, such as magnetic particle imaging (1.7 and 1.35 higher signal respectively for the 3rd and 11th harmonic when compared to Resovist®), or as contrast agents for magnetic resonance imaging (R2/R1 ratio of 17 as compared to 11 at 0.94 T for Resovist®). Moreover, these novel particles can also be used for therapeutic purposes such as hyperthermia, achieving a specific heating power ratio of 208 W/g as compared to 83 W/g for Feridex®, another commercially available product. Therefore, we envision such materials to play a role in the future theranostic applications, where the arginine ability to deliver cargo into the cell can be coupled to the magnetite imaging properties and cancer fighting activity.
View Full-Text
Keywords:
iron oxide; nanoparticle; theranostics; MRI; hyperthermia
▼
Show Figures
Graphical abstract
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
- Supplementary File 1:
PDF-Document (PDF, 467 KiB)
MDPI and ACS Style
Reichel, V.E.; Matuszak, J.; Bente, K.; Heil, T.; Kraupner, A.; Dutz, S.; Cicha, I.; Faivre, D. Magnetite-Arginine Nanoparticles as a Multifunctional Biomedical Tool. Nanomaterials 2020, 10, 2014. https://doi.org/10.3390/nano10102014
AMA Style
Reichel VE, Matuszak J, Bente K, Heil T, Kraupner A, Dutz S, Cicha I, Faivre D. Magnetite-Arginine Nanoparticles as a Multifunctional Biomedical Tool. Nanomaterials. 2020; 10(10):2014. https://doi.org/10.3390/nano10102014
Chicago/Turabian StyleReichel, Victoria E., Jasmin Matuszak, Klaas Bente, Tobias Heil, Alexander Kraupner, Silvio Dutz, Iwona Cicha, and Damien Faivre. 2020. "Magnetite-Arginine Nanoparticles as a Multifunctional Biomedical Tool" Nanomaterials 10, no. 10: 2014. https://doi.org/10.3390/nano10102014
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
