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An Improved Method for Estimating Core Size Distributions of Magnetic Nanoparticles via Magnetization Harmonics

Magnetite-Arginine Nanoparticles as a Multifunctional Biomedical Tool

Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, Am Mühlenberg 1, 14476 Potsdam, Germany
Laboratoire “Matière et Systèmes Complexes” (MSC), UMR 7057 CNRS, Université Paris 7 Diderot, 75205 Paris CEDEX 13, France
Section of Experimental Oncoclogy and Nanomedicine (SEON), ENT Department, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glückstraße 10a, 91054 Erlangen, Germany
Department of Anesthesiology, Kurume University Hospital, Cognitive and MolecularResearch Institute of Brain Diseases, Kurume University, 65-1, Asahimachi, Kurume 830-0011, Japan
Bundesanstalt für Materialforschung und -prüfung, Unter den Eichen 87, 12205 Berlin, Germany
nanoPET Pharma GmbH, Luisencarrée Robert-Koch-Platz 4, 10115 Berlin, Germany
Institute of Biomedical Engineering and Informatics, Technische Universität Ilmenau, PF 100565, 98684 Ilmenau, Germany
Aix-Marseille Université, CEA, CNRS, BIAM, 13108 Saint Paul lez Durance, France
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(10), 2014;
Received: 5 August 2020 / Revised: 1 October 2020 / Accepted: 2 October 2020 / Published: 13 October 2020
(This article belongs to the Special Issue Functional Nanomagnetics and Magneto-Optical Nanomaterials)
Iron oxide nanoparticles are a promising platform for biomedical applications, both in terms of diagnostics and therapeutics. In addition, arginine-rich polypeptides are known to penetrate across cell membranes. Here, we thus introduce a system based on magnetite nanoparticles and the polypeptide poly-l-arginine (polyR-Fe3O4). We show that the hybrid nanoparticles exhibit a low cytotoxicity that is comparable to Resovist®, a commercially available drug. PolyR-Fe3O4 particles perform very well in diagnostic applications, such as magnetic particle imaging (1.7 and 1.35 higher signal respectively for the 3rd and 11th harmonic when compared to Resovist®), or as contrast agents for magnetic resonance imaging (R2/R1 ratio of 17 as compared to 11 at 0.94 T for Resovist®). Moreover, these novel particles can also be used for therapeutic purposes such as hyperthermia, achieving a specific heating power ratio of 208 W/g as compared to 83 W/g for Feridex®, another commercially available product. Therefore, we envision such materials to play a role in the future theranostic applications, where the arginine ability to deliver cargo into the cell can be coupled to the magnetite imaging properties and cancer fighting activity. View Full-Text
Keywords: iron oxide; nanoparticle; theranostics; MRI; hyperthermia iron oxide; nanoparticle; theranostics; MRI; hyperthermia
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MDPI and ACS Style

Reichel, V.E.; Matuszak, J.; Bente, K.; Heil, T.; Kraupner, A.; Dutz, S.; Cicha, I.; Faivre, D. Magnetite-Arginine Nanoparticles as a Multifunctional Biomedical Tool. Nanomaterials 2020, 10, 2014.

AMA Style

Reichel VE, Matuszak J, Bente K, Heil T, Kraupner A, Dutz S, Cicha I, Faivre D. Magnetite-Arginine Nanoparticles as a Multifunctional Biomedical Tool. Nanomaterials. 2020; 10(10):2014.

Chicago/Turabian Style

Reichel, Victoria E., Jasmin Matuszak, Klaas Bente, Tobias Heil, Alexander Kraupner, Silvio Dutz, Iwona Cicha, and Damien Faivre. 2020. "Magnetite-Arginine Nanoparticles as a Multifunctional Biomedical Tool" Nanomaterials 10, no. 10: 2014.

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