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Article

pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery

1
Institute of Chemical Biology and Fundamental Medicine SB RAS, 8, Lavrentiev ave., 630090 Novosibirsk, Russia
2
Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia
3
Laboratoire de Chimie de Coordination, CNRS, 31077 Toulouse, France
4
Research Institute of Fundamental and Clinical Immunology, 630099 Novosibirsk, Russia
5
Departamento de Química Orgánica y Química Inorgánica, UAH-IQAR, Universidad de Alcalá, 28805 Alcalá de Henares, Spain
6
Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain
7
Instituto Ramón y Cajal de Investigación Sanitaria, IRYCIS, 28034 Madrid, Spain
*
Authors to whom correspondence should be addressed.
Nanomaterials 2020, 10(10), 1899; https://doi.org/10.3390/nano10101899
Received: 7 August 2020 / Revised: 21 September 2020 / Accepted: 22 September 2020 / Published: 23 September 2020
(This article belongs to the Special Issue Advances in Nanomaterials in Biomedicine)
Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy. View Full-Text
Keywords: carbosilane; dendron; triazine; amphiphile; self-assembly; vesicles; pH-sensitive; doxorubicin; methotrexate; leukaemia carbosilane; dendron; triazine; amphiphile; self-assembly; vesicles; pH-sensitive; doxorubicin; methotrexate; leukaemia
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MDPI and ACS Style

Apartsin, E.; Knauer, N.; Arkhipova, V.; Pashkina, E.; Aktanova, A.; Poletaeva, J.; Sánchez-Nieves, J.; de la Mata, F.J.; Gómez, R. pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery. Nanomaterials 2020, 10, 1899. https://doi.org/10.3390/nano10101899

AMA Style

Apartsin E, Knauer N, Arkhipova V, Pashkina E, Aktanova A, Poletaeva J, Sánchez-Nieves J, de la Mata FJ, Gómez R. pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery. Nanomaterials. 2020; 10(10):1899. https://doi.org/10.3390/nano10101899

Chicago/Turabian Style

Apartsin, Evgeny, Nadezhda Knauer, Valeria Arkhipova, Ekaterina Pashkina, Alina Aktanova, Julia Poletaeva, Javier Sánchez-Nieves, Francisco J. de la Mata, and Rafael Gómez. 2020. "pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery" Nanomaterials 10, no. 10: 1899. https://doi.org/10.3390/nano10101899

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