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Article

Composite Remineralization of Bone-Collagen Matrices by Low-Temperature Ceramics and Serum Albumin: A New Approach to the Creation of Highly Effective Osteoplastic Materials

by
Vladislav V. Minaychev
1,2,
Anastasia Yu. Teterina
2,
Polina V. Smirnova
2,
Ksenia A. Menshikh
1,3,
Anatoliy S. Senotov
1,
Margarita I. Kobyakova
1,4,
Igor V. Smirnov
2,
Kira V. Pyatina
1,
Kirill S. Krasnov
1,
Roman S. Fadeev
1,
Vladimir S. Komlev
2,* and
Irina S. Fadeeva
1,2,*
1
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Russia
2
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Leninskiy Prospect 49, 119334 Moscow, Russia
3
Center for Translational Research on Autoimmune and Allergic Disease—CAAD, Department of Health Sciences, Università del Piemonte Orientale, 28100 Novara, Italy
4
Research Institute of Clinical and Experimental Lymphology—Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences, 630060 Novosibirsk, Russia
*
Authors to whom correspondence should be addressed.
J. Funct. Biomater. 2024, 15(2), 27; https://doi.org/10.3390/jfb15020027
Submission received: 12 December 2023 / Revised: 16 January 2024 / Accepted: 18 January 2024 / Published: 23 January 2024
(This article belongs to the Section Biomaterials for Tissue Engineering and Regenerative Medicine)
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Abstract

This study examined the effectiveness of coating demineralized bone matrix (DBM) with amorphous calcium phosphate (DBM + CaP), as well as a composite of DBM, calcium phosphate, and serum albumin (DBM + CaP + BSA). The intact structure of DBM promotes the transformation of amorphous calcium phosphate (CaP) into dicalcium phosphate dihydrate (DCPD) with a characteristic plate shape and particle size of 5–35 µm. The inclusion of BSA in the coating resulted in a better and more uniform distribution of CaP on the surface of DBM trabeculae. MG63 cells showed that both the obtained forms of CaP and its complex with BSA did not exhibit cytotoxicity up to a concentration of 10 mg/mL in vitro. Ectopic (subcutaneous) implantation in rats revealed pronounced biocompatibility, as well as strong osteoconductive, osteoinductive, and osteogenic effects for both DBM + CaP and DBM + CaP + BSA, but more pronounced effects for DBM + CaP + BSA. In addition, for the DBM + CaP + BSA samples, there was a pronounced full physiological intrafibrillar biomineralization and proangiogenic effect with the formation of bone-morrow-like niches, accompanied by pronounced processes of intramedullary hematopoiesis, indicating a powerful osteogenic effect of this composite.
Keywords: biomimetic scaffolds; bone grafts; bioactive materials; remineralization; bone tissue engineering; demineralized bone matrix; coatings; calcium phosphate-albumin composite; bone marrow bio-mimetic biomimetic scaffolds; bone grafts; bioactive materials; remineralization; bone tissue engineering; demineralized bone matrix; coatings; calcium phosphate-albumin composite; bone marrow bio-mimetic

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MDPI and ACS Style

Minaychev, V.V.; Teterina, A.Y.; Smirnova, P.V.; Menshikh, K.A.; Senotov, A.S.; Kobyakova, M.I.; Smirnov, I.V.; Pyatina, K.V.; Krasnov, K.S.; Fadeev, R.S.; et al. Composite Remineralization of Bone-Collagen Matrices by Low-Temperature Ceramics and Serum Albumin: A New Approach to the Creation of Highly Effective Osteoplastic Materials. J. Funct. Biomater. 2024, 15, 27. https://doi.org/10.3390/jfb15020027

AMA Style

Minaychev VV, Teterina AY, Smirnova PV, Menshikh KA, Senotov AS, Kobyakova MI, Smirnov IV, Pyatina KV, Krasnov KS, Fadeev RS, et al. Composite Remineralization of Bone-Collagen Matrices by Low-Temperature Ceramics and Serum Albumin: A New Approach to the Creation of Highly Effective Osteoplastic Materials. Journal of Functional Biomaterials. 2024; 15(2):27. https://doi.org/10.3390/jfb15020027

Chicago/Turabian Style

Minaychev, Vladislav V., Anastasia Yu. Teterina, Polina V. Smirnova, Ksenia A. Menshikh, Anatoliy S. Senotov, Margarita I. Kobyakova, Igor V. Smirnov, Kira V. Pyatina, Kirill S. Krasnov, Roman S. Fadeev, and et al. 2024. "Composite Remineralization of Bone-Collagen Matrices by Low-Temperature Ceramics and Serum Albumin: A New Approach to the Creation of Highly Effective Osteoplastic Materials" Journal of Functional Biomaterials 15, no. 2: 27. https://doi.org/10.3390/jfb15020027

APA Style

Minaychev, V. V., Teterina, A. Y., Smirnova, P. V., Menshikh, K. A., Senotov, A. S., Kobyakova, M. I., Smirnov, I. V., Pyatina, K. V., Krasnov, K. S., Fadeev, R. S., Komlev, V. S., & Fadeeva, I. S. (2024). Composite Remineralization of Bone-Collagen Matrices by Low-Temperature Ceramics and Serum Albumin: A New Approach to the Creation of Highly Effective Osteoplastic Materials. Journal of Functional Biomaterials, 15(2), 27. https://doi.org/10.3390/jfb15020027

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