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Article

Nanocomposite Hydrogel Produced from PEGDA and Laponite for Bone Regeneration

by
Leila S. S. M. Magalhães
1,
Danielle B. Andrade
1,2,
Roosevelt D. S. Bezerra
2,
Alan I. S. Morais
1,
Francilio C. Oliveira
3,
Márcia S. Rizzo
1,
Edson C. Silva-Filho
1 and
Anderson O. Lobo
1,*
1
LIMAV—Interdisciplinary Advanced Materials Laboratory, PPGCM—Materials Science and Engineering Graduate Program, UFPI—Federal University of Piaui, Teresina 64049-550, Brazil
2
Federal Institute of Education, Science and Technology of Piauí, Teresina-Central Campus, IFPI, Teresina 64000-040, Brazil
3
Centro Universitário UNINOVAFAPI, Teresina 64073-505, Brazil
*
Author to whom correspondence should be addressed.
J. Funct. Biomater. 2022, 13(2), 53; https://doi.org/10.3390/jfb13020053
Submission received: 2 February 2022 / Revised: 25 April 2022 / Accepted: 28 April 2022 / Published: 4 May 2022
(This article belongs to the Topic Materials in Implant Applications and Regenerative Medicine)
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Abstract

Herein, a nanocomposite hydrogel was produced using laponite and polyethylene-glycol diacrylate (PEGDA), with or without Irgacure (IG), for application in bone tissue regeneration. The nanocomposites were characterized by X-ray diffraction (XRD), Fourier-Transform infrared spectroscopy (FTIR), and thermal analysis (TG/DTG). The XRD results showed that the crystallographic structure of laponite was preserved in the nanocomposite hydrogels after the incorporation of PEGDA and IG. The FTIR results indicated that PEGDA polymer chains were entangled on laponite in hydrogels. The TG/DTG found that the presence of laponite (Lap) improved the thermal stability of nanocomposite hydrogel. The toxicity tests by Artemia salina indicated that the nanocomposite hydrogels were not toxic, because the amount of live nauplii was 80.0%. In addition, in vivo tests demonstrated that the hydrogels had the ability to regenerate bone in a bone defect model of the tibiae of osteopenic rats. For the nanocomposite hydrogel (PEGDA + Lap nanocomposites + UV light), the formation of intramembranous bone in the soft callus was more intense in 66.7% of the animals. Thus, the results presented in this study evidence that nanocomposite hydrogels obtained from laponite and PEGDA have the potential for use in bone regeneration.
Keywords: nanocomposite hydrogel; laponite; PEGDA; bone regeneration nanocomposite hydrogel; laponite; PEGDA; bone regeneration

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MDPI and ACS Style

Magalhães, L.S.S.M.; Andrade, D.B.; Bezerra, R.D.S.; Morais, A.I.S.; Oliveira, F.C.; Rizzo, M.S.; Silva-Filho, E.C.; Lobo, A.O. Nanocomposite Hydrogel Produced from PEGDA and Laponite for Bone Regeneration. J. Funct. Biomater. 2022, 13, 53. https://doi.org/10.3390/jfb13020053

AMA Style

Magalhães LSSM, Andrade DB, Bezerra RDS, Morais AIS, Oliveira FC, Rizzo MS, Silva-Filho EC, Lobo AO. Nanocomposite Hydrogel Produced from PEGDA and Laponite for Bone Regeneration. Journal of Functional Biomaterials. 2022; 13(2):53. https://doi.org/10.3390/jfb13020053

Chicago/Turabian Style

Magalhães, Leila S. S. M., Danielle B. Andrade, Roosevelt D. S. Bezerra, Alan I. S. Morais, Francilio C. Oliveira, Márcia S. Rizzo, Edson C. Silva-Filho, and Anderson O. Lobo. 2022. "Nanocomposite Hydrogel Produced from PEGDA and Laponite for Bone Regeneration" Journal of Functional Biomaterials 13, no. 2: 53. https://doi.org/10.3390/jfb13020053

APA Style

Magalhães, L. S. S. M., Andrade, D. B., Bezerra, R. D. S., Morais, A. I. S., Oliveira, F. C., Rizzo, M. S., Silva-Filho, E. C., & Lobo, A. O. (2022). Nanocomposite Hydrogel Produced from PEGDA and Laponite for Bone Regeneration. Journal of Functional Biomaterials, 13(2), 53. https://doi.org/10.3390/jfb13020053

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