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Article

Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa

1
Institute of Psychiatry and Neuroscience of Paris (IPNP), Université de Paris, INSERM UMR-S 1266, F-75014 Paris, France
2
GHU Paris Psychiatrie et Neurosciences, Hôpital Sainte-Anne, F-75014 Paris, France
3
UMR 7179 CNRS, MNHN, Adaptive mechanism and Evolution (MECADEV), 91800 Brunoy, France
4
Cité scientifique, SN4, Université de Lille, 59491 Villeneuve d’Ascq, France
*
Author to whom correspondence should be addressed.
Both authors contributed equally to this work.
J. Clin. Med. 2020, 9(9), 2782; https://doi.org/10.3390/jcm9092782
Received: 27 July 2020 / Revised: 19 August 2020 / Accepted: 22 August 2020 / Published: 28 August 2020
(This article belongs to the Special Issue Advances in Eating Disorders)
Anorexia nervosa (AN) is a severe metabopsychiatric disorder characterised by caloric intake restriction and often excessive physical exercise. Our aim is to assess in female AN patients and in a rodent model, the co-evolution of physical activity and potential dysregulation of acyl—(AG) and desacyl—(DAG) ghrelin plasma concentrations during denutrition and weight recovery. AN inpatients were evaluated at inclusion (T0, n = 29), half—(T1) and total (T2) weight recovery, and one month after discharge (T3, n = 13). C57/Bl6 mice with access to a running wheel, were fed ad libitum or submitted to short—(15 days) or long—(50 days) term quantitative food restriction, followed by refeeding (20 days). In AN patients, AG and DAG rapidly decreased during weight recovery (T0 to T2), AG increased significantly one-month post discharge (T3), but only DAG plasma concentrations at T3 correlated negatively with BMI and positively with physical activity. In mice, AG and DAG both increased during short- and long-term food restriction. After 20 days of ad libitum feeding, DAG was associated to persistence of exercise alteration. The positive association of DAG with physical activity during caloric restriction and after weight recovery questions its role in the adaptation mechanisms to energy deprivation that need to be considered in recovery process in AN. View Full-Text
Keywords: restrictive anorexia nervosa; weight recovery; animal models; acyl-ghrelin; desacyl-ghrelin; physical activity; chronic food restriction restrictive anorexia nervosa; weight recovery; animal models; acyl-ghrelin; desacyl-ghrelin; physical activity; chronic food restriction
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MDPI and ACS Style

Duriez, P.; Robichon, L.; Dardennes, R.; Lavoisy, G.; Grouselle, D.; Epelbaum, J.; Ramoz, N.; Gorwood, P.; Tolle, V.; Viltart, O. Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa. J. Clin. Med. 2020, 9, 2782. https://doi.org/10.3390/jcm9092782

AMA Style

Duriez P, Robichon L, Dardennes R, Lavoisy G, Grouselle D, Epelbaum J, Ramoz N, Gorwood P, Tolle V, Viltart O. Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa. Journal of Clinical Medicine. 2020; 9(9):2782. https://doi.org/10.3390/jcm9092782

Chicago/Turabian Style

Duriez, Philibert, Lauralee Robichon, Roland Dardennes, Guillaume Lavoisy, Dominique Grouselle, Jacques Epelbaum, Nicolas Ramoz, Philip Gorwood, Virginie Tolle, and Odile Viltart. 2020. "Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa" Journal of Clinical Medicine 9, no. 9: 2782. https://doi.org/10.3390/jcm9092782

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