Next Article in Journal
Contour Changes Following Immediate Placement of Ultra-Wide Implants in Molar Extraction Sockets without Bone Grafting
Next Article in Special Issue
Diagnostic and Clinical Impact of 18F-FDG PET/CT in Staging and Restaging Soft-Tissue Sarcomas of the Extremities and Trunk: Mono-Institutional Retrospective Study of a Sarcoma Referral Center
Previous Article in Journal
Survival in Patients with Neuroendocrine Tumours of the Small Intestine: Nomogram Validation and Predictors of Survival
Previous Article in Special Issue
Hypofractionated Radiotherapy in Locally Advanced Myxoid Liposarcomas of Extremities or Trunk Wall: Results of a Single-Arm Prospective Clinical Trial
Open AccessArticle

The Real-Life Journey of Elderly Patients in Soft Tissue and Bone Sarcomas: A Retrospective Analysis from a Sarcoma Referral Center

1
First Division of Medical Oncology, IRCCS-Regina Elena National Cancer Institute, 00161 Rome, Italy
2
Oncological Orthopaedics Unit, IRCCS-Regina Elena National Cancer Institute, 00161 Rome, Italy
3
Psychology Unit, IRCCS-Regina Elena National Cancer Institute, 00161 Rome, Italy
4
Biostatistic Unit—Scientific Direction, IRCCS-Regina Elena National Cancer Institute, 00161 Rome, Italy
5
Department of Radiation Oncology, IRCCS-Regina Elena National Cancer Institute, 00161 Rome, Italy
6
Epidemiology and Cancer Registry Unit, IRCCS-Regina Elena National Cancer Institute, 00161 Rome, Italy
7
Nuclear Medicine Unit, IRCCS-Regina Elena National Cancer Institute, 00161 Rome, Italy
8
Radiology and Diagnostic Imaging Unit, IRCCS-Regina Elena National Cancer Institute, 00161 Rome, Italy
9
Pathology, IRCCS-Regina Elena National Cancer Institute, 00161 Rome, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(8), 2503; https://doi.org/10.3390/jcm9082503
Received: 27 June 2020 / Revised: 19 July 2020 / Accepted: 28 July 2020 / Published: 4 August 2020
The high complexity of multimodality treatment frequently results in undertreatment of elderly sarcoma patients, and this may be one of the factors that influence their prognosis. We describe the real-life approach to a population of patients aged over 70 with both soft tissue (STS) and bone sarcomas (BS) followed by our Sarcoma Disease Management Team from 2012 to 2017. One-hundred and twenty-three patients with a median age of 77 years (range: 70–92) were identified. STS were the most common histological subtypes (94%) and the grade was high in 79/123 patients (64%). At diagnosis, 88% of patients had localized disease (LD) and 12% were metastatic (MD). Overall, 96% of patients with LD underwent surgery, 46/54 (85%) with high grade STS patients underwent complementary radiotherapy, and 10/54 (19%) received adjuvant treatments. Twelve out of 33 patients who relapsed (36%) underwent local therapies. Seventeen (52%) and eight (24%) patients were treated with first-line and second-line medical treatments, respectively. Tolerability to systemic treatments was fairly good. Overall, 21% of the patients with advanced disease were candidates for best supportive care alone. Our case series of elderly patients with both STS and BS shows that personalized multidisciplinary treatment can nevertheless be offered to this frail population in order to control the evolution of disease. View Full-Text
Keywords: soft tissue sarcomas; bone sarcomas; elderly patients; surgery; radiotherapy; medical treatments; multidisciplinary treatment soft tissue sarcomas; bone sarcomas; elderly patients; surgery; radiotherapy; medical treatments; multidisciplinary treatment
Show Figures

Figure 1

MDPI and ACS Style

Ferraresi, V.; Vari, S.; Rossi, B.; Maggi, G.; Giannarelli, D.; Persichetti, A.; Petrongari, M.G.; Cercato, M.C.; Annovazzi, A.; Anelli, V.; Pescarmona, E.; Baldi, J.; Zoccali, C.; Pellegrini, D.; Cognetti, F.; Biagini, R. The Real-Life Journey of Elderly Patients in Soft Tissue and Bone Sarcomas: A Retrospective Analysis from a Sarcoma Referral Center. J. Clin. Med. 2020, 9, 2503.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop