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Open AccessArticle

Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study

1
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain
2
IIORC, Faculty of Medicine, 28011 Madrid, Spain
3
Facultad de Óptica y Optometría, Departamento de Inmunología, Oftalmología y ORL, UCM, 28037 Madrid, Spain
4
Hospital General Universitario Gregorio Marañón, Instituto Oftálmico de Madrid, 28007 Madrid, Spain
5
Endocrinology and Nutrition Department, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, 28040 Madrid, Spain
6
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, 28029 Madrid, Spain
7
Facultad de Medicina, Departamento de Inmunología, Oftalmología y ORL, UCM, 28040 Madrid, Spain
*
Authors to whom correspondence should be addressed.
These authors (I.L.-C. and R.d.H.) contributed equally to this work.
J. Clin. Med. 2020, 9(6), 1728; https://doi.org/10.3390/jcm9061728
Received: 2 May 2020 / Revised: 29 May 2020 / Accepted: 1 June 2020 / Published: 3 June 2020
In this case control study, we examined the retinal thickness of the different layers in the macular region and peripapillary retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) in healthy cognitive subjects (from 51 to 74 years old) at high genetic risk for developing Alzheimer’s disease (AD). Thirty-five subjects with a family history of Alzheimer disease (AD) (FH+) and ApoE ɛ4 carriers and 29 age-matched control subjects without a family history of AD (FH−) and ApoE ɛ4 non-carriers were included. Compared to FH− ApoE ɛ4 non-carriers, in FH+ ApoE ɛ4 carriers, there were statistically significant decreases (p < 0.05) in (i) the foveal area of mRNFL; (ii) the inferior and nasal sectors in the outer and inner macular ring in the inner plexiform layer (IPL); (iii) the foveal area and the inferior sector in the outer macular ring in the inner nuclear layer (INL); and (iv) the inferior sector of the outer macular ring in the outer plexiform layer (OPL). However, no statistically significant differences were found in the peripapillary thickness of RNFL between both study groups. In subjects with cognitive health and high genetic risk for the development of AD, initial changes appeared in the macular area. OCT could be a promising, cost-effective and non-invasive test useful in early AD, before the onset of clinical symptoms. View Full-Text
Keywords: Alzheimer´s disease; ApoE ɛ4; first-degree family history; genetic risk; OCT; retina Alzheimer´s disease; ApoE ɛ4; first-degree family history; genetic risk; OCT; retina
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López-Cuenca, I.; de Hoz, R.; Salobrar-García, E.; Elvira-Hurtado, L.; Rojas, P.; Fernández-Albarral, J.A.; Barabash, A.; Salazar, J.J.; Ramírez, A.I.; Ramírez, J.M. Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study. J. Clin. Med. 2020, 9, 1728.

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