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High Risk of Sustained Ventricular Arrhythmia Recurrence After Acute Myocarditis

1
Cardiology Department, Dijon Bourgogne University Hospital, 21000 Dijon, France
2
Cardiology Department, Hôpitaux Universitaires Pitié Salpêtrière, APHP, 75013 Paris, France
3
Cardiology Department, University Hospital, 35000 Rennes, France
4
Institut du thorax, Service de Cardiologie and INSERM 1087, 44000 Nantes, France
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Cardiology Department, European Georges Pompidou Hospital and Paris Descartes University, 75015 Paris, France
6
Cardiology Department, University Hospital, 54511 Nancy, France
7
Cardiology Department, University Hospital Louis Pradel, 69500 Lyon, France
8
Cardiology Department, University Hospital, 42055 Saint-Etienne, France
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Cardiology Department, University Hospital, 25030 Besançon, France
10
Aix-Marseille University, Assistance Publique–Hôpitaux de Marseille (APHM), Department of Cardiology, Nord Hospital, 13000 Marseille, France
11
Cardiology Department, CHU Clermont-Ferrand, Clermont-Ferrand, France and Université Clermont Auvergne, CHU Clermont-Ferrand, CNRS, SIGMA Clermont, Institut Pascal, 63000 Clermont-Ferrand, France
12
Cardiology Department, University Hospital, 51100 Reims, France
13
CHU Poitiers, Centre Cardiovasculaire, 86000 Poitiers, France
14
Cardiology Department, University Hospital, 29200 Brest, France
15
Department of Cardiology, Bichat Claude Bernard Hospital, University Paris Diderot, 75018 Paris, France
16
Internal Medicine 2 Department, Dijon Bourgogne University Hospital, 21000 Dijon, France
17
PEC 2, Univ. Bourgogne Franche–Comté, 21000 Dijon, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.
J. Clin. Med. 2020, 9(3), 848; https://doi.org/10.3390/jcm9030848
Received: 21 February 2020 / Revised: 10 March 2020 / Accepted: 19 March 2020 / Published: 20 March 2020
(This article belongs to the Section Cardiology)
Acute myocarditis is associated with cardiac arrhythmia in 25% of cases; a third of these arrhythmias are ventricular tachycardia (VT) or ventricular fibrillation (VF). The implantation of a cardiac defibrillator (ICD) following sustained ventricular arrhythmia remains controversial in these patients. We sought to assess the risk of major arrhythmic ventricular events (MAEs) over time in patients implanted with an ICD following sustained VT/VF in the acute phase of myocarditis compared to those implanted for VT/VF occurring on myocarditis sequelae. Our retrospective observational study included patients implanted with an ICD following VT/VF during acute myocarditis or VT/VF on myocarditis sequelae, from 2007 to 2017, in 15 French university hospitals. Over a median follow-up period of 3 years, MAE occurred in 11 (39%) patients of the acute myocarditis group and 24 (60%) patients of the myocarditis sequelae group. Kaplan–Meier MAE rate estimates at one and three years of follow-up were 19% and 45% in the acute group, and 43% and 64% in the sequelae group. Patients who experienced sustained ventricular arrhythmias during acute myocarditis had a very high risk of VT/VF recurrence during follow-up. These results show that the risk of MAE recurrence remains high after resolution of the acute episode. View Full-Text
Keywords: myocarditis; ventricular tachycardia; ventricular fibrillation; implantable cardioverter defibrillator myocarditis; ventricular tachycardia; ventricular fibrillation; implantable cardioverter defibrillator
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MDPI and ACS Style

Rosier, L.; Zouaghi, A.; Barré, V.; Martins, R.; Probst, V.; Marijon, E.; Sadoul, N.; Chauveau, S.; Da Costa, A.; Badoz, M.; Peyrol, M.; Barraud, J.; Massoullie, G.; Eschalier, R.; Espinosa, M.; Lesaffre, F.; Garcia, R.; Degand, B.; Noël, A.; Mansourati, J.; Extramiana, F.; Algalarrondo, V.; Devilliers, H.; Cottin, Y.; Gandjbakhch, E.; Guenancia, C. High Risk of Sustained Ventricular Arrhythmia Recurrence After Acute Myocarditis. J. Clin. Med. 2020, 9, 848.

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