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Open AccessArticle

Using Whole Breast Ultrasound Tomography to Improve Breast Cancer Risk Assessment: A Novel Risk Factor Based on the Quantitative Tissue Property of Sound Speed

1
Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA
2
Delphinus Medical Technologies, Novi, MI 48374, USA
3
School of Medicine, Wayne State University, Detroit, MI 48201, USA
4
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
5
Henry Ford Health Systems, Detroit, MI 48202, USA
6
Department of Radiology, George Washington University, Washington, DC 20037, USA
7
Mayo Clinic, Jacksonville, FL 32224, USA
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(2), 367; https://doi.org/10.3390/jcm9020367
Received: 31 December 2019 / Revised: 18 January 2020 / Accepted: 20 January 2020 / Published: 29 January 2020
(This article belongs to the Special Issue Mammographic Density: Biology and Clinical Applications)
Mammographic percent density (MPD) is an independent risk factor for developing breast cancer, but its inclusion in clinical risk models provides only modest improvements in individualized risk prediction, and MPD is not typically assessed in younger women because of ionizing radiation concerns. Previous studies have shown that tissue sound speed, derived from whole breast ultrasound tomography (UST), a non-ionizing modality, is a potential surrogate marker of breast density, but prior to this study, sound speed has not been directly linked to breast cancer risk. To that end, we explored the relation of sound speed and MPD with breast cancer risk in a case-control study, including 61 cases with recent breast cancer diagnoses and a comparison group of 165 women, frequency matched to cases on age, race, and menopausal status, and with a recent negative mammogram and no personal history of breast cancer. Multivariable odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the relation of quartiles of MPD and sound speed with breast cancer risk adjusted for matching factors. Elevated MPD was associated with increased breast cancer risk, although the trend did not reach statistical significance (OR per quartile = 1.27, 95% CI: 0.95, 1.70; ptrend = 0.10). In contrast, elevated sound speed was significantly associated with breast cancer risk in a dose–response fashion (OR per quartile = 1.83, 95% CI: 1.32, 2.54; ptrend = 0.0003). The OR trend for sound speed was statistically significantly different from that observed for MPD (p = 0.005). These findings suggest that whole breast sound speed may be more strongly associated with breast cancer risk than MPD and offer future opportunities for refining the magnitude and precision of risk associations in larger, population-based studies, including women younger than usual screening ages. View Full-Text
Keywords: breast neoplasms; mammographic breast density; risk factors; ultrasound tomography; sound speed breast neoplasms; mammographic breast density; risk factors; ultrasound tomography; sound speed
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MDPI and ACS Style

Duric, N.; Sak, M.; Fan, S.; Pfeiffer, R.M.; Littrup, P.J.; Simon, M.S.; Gorski, D.H.; Ali, H.; Purrington, K.S.; Brem, R.F.; Sherman, M.E.; Gierach, G.L. Using Whole Breast Ultrasound Tomography to Improve Breast Cancer Risk Assessment: A Novel Risk Factor Based on the Quantitative Tissue Property of Sound Speed. J. Clin. Med. 2020, 9, 367. https://doi.org/10.3390/jcm9020367

AMA Style

Duric N, Sak M, Fan S, Pfeiffer RM, Littrup PJ, Simon MS, Gorski DH, Ali H, Purrington KS, Brem RF, Sherman ME, Gierach GL. Using Whole Breast Ultrasound Tomography to Improve Breast Cancer Risk Assessment: A Novel Risk Factor Based on the Quantitative Tissue Property of Sound Speed. Journal of Clinical Medicine. 2020; 9(2):367. https://doi.org/10.3390/jcm9020367

Chicago/Turabian Style

Duric, Neb; Sak, Mark; Fan, Shaoqi; Pfeiffer, Ruth M.; Littrup, Peter J.; Simon, Michael S.; Gorski, David H.; Ali, Haythem; Purrington, Kristen S.; Brem, Rachel F.; Sherman, Mark E.; Gierach, Gretchen L. 2020. "Using Whole Breast Ultrasound Tomography to Improve Breast Cancer Risk Assessment: A Novel Risk Factor Based on the Quantitative Tissue Property of Sound Speed" J. Clin. Med. 9, no. 2: 367. https://doi.org/10.3390/jcm9020367

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