Next Article in Journal
Rituximab Use in Warm and Cold Autoimmune Hemolytic Anemia
Previous Article in Journal
Cellular Proliferation, Dermal Repair, and Microbiological Effectiveness of Ultrasound-Assisted Wound Debridement (UAW) Versus Standard Wound Treatment in Complicated Diabetic Foot Ulcers (DFU): An Open-Label Randomized Controlled Trial
Previous Article in Special Issue
Clinical Significance of ARID1A and ANXA1 in HER-2 Positive Breast Cancer
Open AccessArticle

Discordance between Primary Breast Cancer and Ipsilateral Breast Cancer Tumor Recurrence as a Function of Distance

1
Department of Gynecology and Obstetrics, Erlangen University Hospital, Comprehensive Cancer Center, European Metropolitan Area Erlangen-Nuremberg (CCC ER-EMN), Friedrich Alexander University of Erlangen-Nuremberg, 91054 Erlangen, Germany
2
Freelance Computer Scientist, 85049 Ingolstadt, Germany
3
Department of Biometry and Epidemiology, Friedrich Alexander University of Erlangen-Nuremberg, 91054 Erlangen, Germany
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(12), 4033; https://doi.org/10.3390/jcm9124033
Received: 30 October 2020 / Revised: 29 November 2020 / Accepted: 7 December 2020 / Published: 13 December 2020
(This article belongs to the Special Issue Advances in the Diagnosis and Therapy of Breast Cancer)
Background: Risk factors for ipsilateral breast cancer tumor recurrence (IBTR) are well established and include grading, nodal status, and receptor status. Little is known about the influence of the local distance between the primary tumor and recurrences on changes in tumor characteristics and prognosis. Methods: In a retrospective setting, we analyzed primary breast cancers and their recurrences. Localizations of primary and recurrent breast cancer were recorded to calculate the relative distance in pixels. Analysis was performed regarding tumor characteristics, relative distance between both, and their impact on breast cancer prognosis. Results: In a cohort of 142 patients with ipsilateral recurrence, no statistically significant difference could be shown in the change in tumor characteristics depending on distance. Progesterone receptor (PR) and estrogene receptor (ER) status changed in 22.7% and 14.9% of cases, respectively. human epidermal growth factor receptor 2 (ERBB2, HER2) status changed in 18.3% of cases. Survival was in accordance with the literature, with luminal-A-like tumors as best and triple negative breast cancers (TNBC) as worst prognosis. With a threshold of 162 pixels, the survival was significantly better in the group with shorter distance. Conclusion: Change in tumor characteristics from primary breast cancer to recurrence occurs more often in PR than ER. In contrast to other work, in this dataset, recurrences with a larger distance to the primary tumor had a worse prognosis in univariate analysis. A Cox model might indicate the possibility that this influence is independent of other risk factors. View Full-Text
Keywords: breast cancer; ipsilateral recurrence; prognosis; tumor characteristics breast cancer; ipsilateral recurrence; prognosis; tumor characteristics
Show Figures

Figure 1

MDPI and ACS Style

Jud, S.M.; Hatko, R.; Emons, J.; Lauterbach, B.; Hack, C.C.; Preuß, C.; Adler, W.; Beckmann, M.W.; Heindl, F. Discordance between Primary Breast Cancer and Ipsilateral Breast Cancer Tumor Recurrence as a Function of Distance. J. Clin. Med. 2020, 9, 4033. https://doi.org/10.3390/jcm9124033

AMA Style

Jud SM, Hatko R, Emons J, Lauterbach B, Hack CC, Preuß C, Adler W, Beckmann MW, Heindl F. Discordance between Primary Breast Cancer and Ipsilateral Breast Cancer Tumor Recurrence as a Function of Distance. Journal of Clinical Medicine. 2020; 9(12):4033. https://doi.org/10.3390/jcm9124033

Chicago/Turabian Style

Jud, Sebastian M.; Hatko, Reinhard; Emons, Julius; Lauterbach, Bianca; Hack, Carolin C.; Preuß, Caroline; Adler, Werner; Beckmann, Matthias W.; Heindl, Felix. 2020. "Discordance between Primary Breast Cancer and Ipsilateral Breast Cancer Tumor Recurrence as a Function of Distance" J. Clin. Med. 9, no. 12: 4033. https://doi.org/10.3390/jcm9124033

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop