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Open AccessArticle

Factors Associated with Ocular and Extraocular Recovery in 143 Patients with Sarcoid Uveitis

1
Department of Internal Medicine, Hôpital de la Croix-Rousse, Université Claude Bernard Lyon 1, 69004 Lyon, France
2
Hospices Civils de Lyon, Pôle Santé Publique, Service de Biostatistique et Bioinformatique, F-69003 Lyon, France
3
CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Évolutive, Équipe Biostatistique-Santé, F-69100 Villeurbanne, France
4
Department of Ophthalmology, Hôpital de la Croix-Rousse, Université Claude Bernard Lyon 1, 69004 Lyon, France
5
Laboratoire UMR-CNRS 5510 Matéis, Université Lyon 1, 69100 Villeurbanne, France
6
Department of Internal Medicine, Centre Hospitalier Saint-Joseph Saint-Luc, Université Claude Bernard Lyon 1, 69007 Lyon, France
7
Department of Ophthalmology, Hôpital Edouard Herriot, Université Claude Bernard Lyon 1, 69003 Lyon, France
8
Department of Internal Medicine, Hôpital Edouard Herriot, Université Claude Bernard Lyon 1, 69003 Lyon, France
9
Hospices Civils de Lyon, Pôle IMER, Lyon F-69003, France
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(12), 3894; https://doi.org/10.3390/jcm9123894
Received: 15 November 2020 / Accepted: 28 November 2020 / Published: 30 November 2020
Background: Sarcoidosis is one of the leading causes of uveitis. To date, no studies have assessed the factors specifically related with recovery in ocular sarcoidosis. In this study, we aimed to determine factors associated with ocular and extraocular recovery in patients with sarcoid uveitis. Methods: A retrospective study of sarcoid uveitis, with a three-year minimum follow-up in Lyon University Hospital between December 2003 and December 2019. Patients presented biopsy-proven sarcoidosis or presumed sarcoid. Recovery was defined by a disease-free status, spontaneously or despite being off all treatments for three years or more. Results: 143 patients were included: 110 with biopsy-proven and 33 with presumed sarcoid uveitis. Seventy-one percent were women, the median age at presentation was 53 years, and 71% were Caucasian. Chronic uveitis was the main clinical presentation (75%), mostly panuveitis (48%) with bilateral involvement (82%). After a median follow-up of 83.5 months, recovery was reported in 26% of patients. In multivariable analysis, Caucasian ethnicity (p = 0.007) and anterior uveitis (p = 0.008) were significantly associated with recovery, while increased intraocular pressure was negatively associated (p = 0.039). Conclusion: In this large European cohort, one quarter of patients recovered. Caucasian ethnicity and anterior uveitis are associated with ocular and extraocular recovery. View Full-Text
Keywords: uveitis; sarcoidosis recovery uveitis; sarcoidosis recovery
MDPI and ACS Style

Bienvenu, F.-H.; Tiffet, T.; Maucort-Boulch, D.; Gerfaud-Valentin, M.; Kodjikian, L.; Perard, L.; Burillon, C.; Durel, C.-A.; Hot, A.; Jamilloux, Y.; Seve, P. Factors Associated with Ocular and Extraocular Recovery in 143 Patients with Sarcoid Uveitis. J. Clin. Med. 2020, 9, 3894. https://doi.org/10.3390/jcm9123894

AMA Style

Bienvenu F-H, Tiffet T, Maucort-Boulch D, Gerfaud-Valentin M, Kodjikian L, Perard L, Burillon C, Durel C-A, Hot A, Jamilloux Y, Seve P. Factors Associated with Ocular and Extraocular Recovery in 143 Patients with Sarcoid Uveitis. Journal of Clinical Medicine. 2020; 9(12):3894. https://doi.org/10.3390/jcm9123894

Chicago/Turabian Style

Bienvenu, Francois-Henri; Tiffet, Théophile; Maucort-Boulch, Delphine; Gerfaud-Valentin, Mathieu; Kodjikian, Laurent; Perard, Laurent; Burillon, Carole; Durel, Cécile-Audrey; Hot, Arnaud; Jamilloux, Yvan; Seve, Pascal. 2020. "Factors Associated with Ocular and Extraocular Recovery in 143 Patients with Sarcoid Uveitis" J. Clin. Med. 9, no. 12: 3894. https://doi.org/10.3390/jcm9123894

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