Effect of Excessive Body Weight and Psoriasis in Women Undergoing ICSI Procedure and State of Health of the Newborn
Abstract
:1. Introduction
2. Material and Methods
2.1. The Study Patients
2.2. Characteristics of Psoriasis in the Study Patients
2.3. Characteristics of the Study Patients
- Healthy women with normal-weight (18.5–24.9 kg/m2) (N = 55);
- Healthy women with overweight (25–29.9 kg/m2) or Class I obesity (30–34.9 kg/m2) (N = 55);
- Normal weight with psoriasis (N = 15);
- Overweight or Class I obesity with psoriasis (N = 15).
2.4. The Study Protocol
2.5. Oocyte Quality
2.6. Blastocyst Quality
- Excellent (≥3AA);
- Good (3–6AB, 3–6BA, 1–2AA);
- Average (3–6BB, 3–6AC, 3–6CA, 1–2AB, 1–2BA);
- Poor (1–6BC, 1–6CB, 1–6CC, 1–2BB) grade blastocysts.
2.7. Statistical Methods
- Mann–Whitney U test to compare numerical variables: in healthy women between normal weight and overweight or Class I obesity, in psoriatic women between normal weight and overweight or Class I obesity, in healthy women with overweight or Class I obesity versus psoriatic women with overweight or Class I obesity, in healthy women with normal weight versus psoriatic women with normal weight;
- Pearson’s chi-square test to compare the categorical variables in healthy women between normal weight and overweight or Class I obesity, in psoriatic women between normal weight and overweight or Class I obesity;
- Pearson’s correlation coefficient to correlate BMI with numerical variables.
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Parameter | Healthy Women | Psoriatic Women | p3 | p4 | ||||
---|---|---|---|---|---|---|---|---|
Normal Weight (N = 55) | Overweight or Class I Obesity (N = 55) | p1 | Normal Weight (N = 15) | Overweight or Class I Obesity (N = 15) | p2 | |||
Age (years) | 31.80 ± 1.89 | 31.87 ± 2.12 | 0.92 | 31.67 ± 1.35 | 31.67 ± 1.50 | 0.93 | 0.63 | 0.458 |
AMH (pmol/L) | 3.03 ± 0.95 | 2.95 ± 0.83 | 0.58 | 3.27 ± 0.76 | 2.93 ± 0.82 | 0.19 | 0.98 | 0.44 |
Total amount of rFSH (IU) | 1301 ± 187 | 1640 ± 343 | <0.001 | 1370 ± 169 | 1790 ± 378 | 0.001 | 0.13 | 0.047 |
Endometrial thickness (mm) | 11.71 ± 1.48 | 12.08 ± 2.05 | 0.24 | 12.47 ± 1.08 | 12.16 ± 2.20 | 0.98 | 0.84 | 0.06 |
E2 (pg/mL) | 2379 ± 1461 | 1478 ± 1013 | <0.001 | 1989 ± 483 | 1216 ± 382 | <0.001 | 0.65 | 0.98 |
Number of follicles aspirated | 8.27 ± 2.66 | 7.62 ± 2.97 | 0.06 | 7.60 ± 1.30 | 7.27 ± 1.53 | 0.47 | 0.94 | 0.50 |
Number of oocytes retrieved | 7.73 ± 2.58 | 6.02 ± 2.31 | <0.001 | 7.20 ± 1.37 | 4.60 ± 0.91 | <0.001 | 0.006 | 0.68 |
Total recovery rate | 0.94 ± 0.09 | 0.80 ± 0.15 | <0.001 | 0.95 ± 0.07 | 0.65 ± 0.13 | <0.001 | 0.001 | 0.88 |
Average TOS | 2.45 ± 0.87 | 0.91 ± 0.96 | <0.001 | 2.46 ± 0.82 | 1.33 ± 1.12 | 0.007 | 0.74 | 0.90 |
Average TOS of oocytes developed to transferred blastocysts | 5.55 ± 0.57 | 3.89 ± 1.10 | <0.001 | 5.57 ± 0.37 | 2.97 ± 0.83 | <0.001 | 0.003 | 0.60 |
Number of frozen blastocysts | 3.07 ± 2.16 | 0.64 ± 0.95 | <0.001 | 2.47 ± 1.30 | 0.60 ± 0.74 | <0.001 | 0.81 | 0.93 |
Number of all blastocysts (transferred + frozen) | 4.93 ± 1.95 | 2.38 ± 1.18 | <0.001 | 4.47 ± 1.30 | 2.47 ± 0.92 | <0.001 | 0.56 | 0.56 |
BFR | 0.64 ± 0.13 | 0.55 ± 0.23 | <0.001 | 0.62 ± 0.12 | 0.40 ± 0.14 | 0.12 | 0.016 | 0.64 |
Average blastocyst quality | 2.79 ± 0.79 | 2.00 ± 0.38 | <0.001 | 2.37 ± 0.67 | 1.82 ± 0.21 | 0.002 | 0.11 | 0.07 |
Average quality of transferred blastocysts | 2.61 ± 0.91 | 1.42 ± 0.53 | <0.001 | 2.20 ± 0.68 | 1.23 ± 0.37 | <0.001 | 0.15 | 0.27 |
Parameter | Healthy Women | Psoriatic Women | p3 | p4 | ||||
---|---|---|---|---|---|---|---|---|
Normal Weight (N = 55) | Overweight or Class I Obesity (N = 55) | p1 | Normal Weight (N = 15) | Overweight or Class I Obesity (N = 15) | p2 | |||
Live births, n (%) | 20 (36.36) | 13 (23.64) | 0.14 | 6 (40.00) | 2 (13.33) | 0.09 | 0.39 | 0.80 |
Complications during pregnancy, n (%) | ||||||||
gestational diabetes | 2 (3.64) | 4 (7.27) | 0.40 | 0 (0.00) | 5 (33.33) | 0.005 | 0.008 | 0.44 |
gestational hypertension | 0 (0.00) | 3 (5.45) | 0.039 | 0 (0.00) | 1 (6.67) | 0.23 | 0.86 | 0.99 |
gestational protein uric hypertension | 1 (1.82) | 3 (5.45) | 0.30 | 0 (0.00) | 3 (20.00) | 0.034 | 0.74 | 0.60 |
intrauterine growth | 1 (1.82) | 5 (9.09) | 0.08 | 4 (26.67) | 5 (33.33) | 0.69 | 0.021 | <0.001 |
Gestational age (weeks) at delivery, M±SD | 38.85 ± 1.42 | 37.38 ± 1.71 | 0.006 | 37.33 ± 2.34 | 34.50 ± 0.71 | 0.24 | 0.07 | 0.11 |
Parameter | Healthy Women (N = 110) | Psoriatic Women (N = 30) | ||
---|---|---|---|---|
r | p | r | p | |
Age (years) | 0.045 | 0.64 | 0.028 | 0.88 |
AMH (pmol/L) | 0.029 | 0.77 | −0.250 | 0.18 |
Total amount of rFSH (IU) | 0.437 | <0.001 | 0.333 | 0.07 |
Endometrial thickness (mm) | 0.060 | 0.53 | −0.005 | 0.98 |
E2 (pg/mL) | −0.222 | 0.020 | −0.596 | 0.001 |
Number of follicles aspirated | 0.022 | 0.82 | −0.043 | 0.82 |
Number of oocytes retrieved | −0.198 | 0.038 | −0.638 | <0.001 |
Total recovery rate | −0.471 | <0.001 | −0.703 | <0.001 |
Average TOS | −0.581 | <0.001 | −0.422 | 0.020 |
Average TOS of oocytes developed to transferred blastocysts | −0.596 | <0.001 | −0.739 | <0.001 |
Number of frozen blastocysts | −0.512 | <0.001 | −0.541 | 0.002 |
Number of all blastocysts (transferred + frozen) | −0.540 | <0.001 | −0.587 | 0.001 |
BFR | −0.647 | <0.001 | −0.176 | 0.35 |
Average blastocyst quality | −0.493 | <0.001 | −0.254 | 0.18 |
Average quality of transferred blastocysts | −0.556 | <0.001 | −0.414 | 0.023 |
Gestational age (weeks) at delivery | −0.444 | 0.010 | −0.303 | 0.47 |
APGAR | −0.481 | 0.005 | −0.356 | 0.39 |
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Wdowiak-Filip, A.; Wdowiak, A.; Raczkiewicz, D.; Bartosińska, J.; Bojar, I. Effect of Excessive Body Weight and Psoriasis in Women Undergoing ICSI Procedure and State of Health of the Newborn. J. Clin. Med. 2020, 9, 3628. https://doi.org/10.3390/jcm9113628
Wdowiak-Filip A, Wdowiak A, Raczkiewicz D, Bartosińska J, Bojar I. Effect of Excessive Body Weight and Psoriasis in Women Undergoing ICSI Procedure and State of Health of the Newborn. Journal of Clinical Medicine. 2020; 9(11):3628. https://doi.org/10.3390/jcm9113628
Chicago/Turabian StyleWdowiak-Filip, Anita, Artur Wdowiak, Dorota Raczkiewicz, Joanna Bartosińska, and Iwona Bojar. 2020. "Effect of Excessive Body Weight and Psoriasis in Women Undergoing ICSI Procedure and State of Health of the Newborn" Journal of Clinical Medicine 9, no. 11: 3628. https://doi.org/10.3390/jcm9113628