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Article

Coagulation Parameters: An Efficient Measure for Predicting the Prognosis and Clinical Management of Patients with COVID-19

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Intensive Care Unit, La Paz University Hospital, Research Group BPM, Idi-Paz Research Institute, Paseo de la Castellana, 261, 28046 Madrid, Spain
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Research Group BPM, Idi-Paz Research Institute, University Rey Juan Carlos, Calle de Pedro Rico, 6, 28029 Madrid, Spain
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Research Unit in Primary Care, IIS Aragón, Avda, University of Zaragoza, San Juan Bosco, 13, 50009 Zaragoza, Spain
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Faculty of Health Sciences, La Rioja University, Edificio de Rectorado, Av. de la Paz, 93, 26006 Logroño, Spain
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Nursing School La Fe, Adscript Center of University of Valencia, Research Group GREIACC, Health Research Institute La Fe, Avda, Fernando Abril Martorell 106, Pabellón Docente Torre H, 46006 Valencia, Spain
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Authors to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(11), 3482; https://doi.org/10.3390/jcm9113482
Received: 11 September 2020 / Revised: 26 September 2020 / Accepted: 26 October 2020 / Published: 28 October 2020
(This article belongs to the Special Issue Vascular Damage and Coagulopathy during COVID-19 Infections)
Background. COVID-19 is an ongoing global pandemic. Since the detection of the first cases of coronavirus disease 2019 (COVID-19) in Wuhan, China, the current pandemic has affected more than 25.3 million people worldwide. The aim of this study was to evaluate the relationship between coagulation abnormalities and prognosis in a cohort of patients with COVID-19. Methods. We performed a retrospective cohort study of 3581 patients admitted to Hospital La Paz (Madrid, Spain) due to respiratory infection by severe acute respiratory syndrome coronavirus from the beginning of the current pandemic to 15 July 2020. Results. Of the 3581 study patients, 48.94% were men, and 19.80% were healthcare workers. The median age was 62 years. Compared with the survivors, the non-survivors had lower prothrombin activity (82.5 (Interquartile range—IQR, 67–95) vs. 95.25 (IQR, 87–104) for non-survivors and survivors, respectively; p < 0.001), higher fibrinogen levels (748.5—IQR, 557–960) vs. 572.75 (IQR, 417–758; p < 0.001), and notably higher D-dimer levels (2329—IQR, 1086.12–5670.40) vs. 635.5 (IQR, 325.5–1194.8); p < 0.001). Conclusions. The evaluation of coagulation parameters could be an efficient measure for predicting the prognosis and improving the clinical management of patients with COVID-19. View Full-Text
Keywords: coronavirus; COVID-19; SARS-CoV-2; coagulation coronavirus; COVID-19; SARS-CoV-2; coagulation
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MDPI and ACS Style

Quintana-Díaz, M.; Andrés-Esteban, E.M.; Ramírez-Cervantes, K.L.; Olivan-Blázquez, B.; Juárez-Vela, R.; Gea-Caballero, V. Coagulation Parameters: An Efficient Measure for Predicting the Prognosis and Clinical Management of Patients with COVID-19. J. Clin. Med. 2020, 9, 3482. https://doi.org/10.3390/jcm9113482

AMA Style

Quintana-Díaz M, Andrés-Esteban EM, Ramírez-Cervantes KL, Olivan-Blázquez B, Juárez-Vela R, Gea-Caballero V. Coagulation Parameters: An Efficient Measure for Predicting the Prognosis and Clinical Management of Patients with COVID-19. Journal of Clinical Medicine. 2020; 9(11):3482. https://doi.org/10.3390/jcm9113482

Chicago/Turabian Style

Quintana-Díaz, Manuel, Eva M. Andrés-Esteban, Karen L. Ramírez-Cervantes, Bárbara Olivan-Blázquez, Raúl Juárez-Vela, and Vicente Gea-Caballero. 2020. "Coagulation Parameters: An Efficient Measure for Predicting the Prognosis and Clinical Management of Patients with COVID-19" Journal of Clinical Medicine 9, no. 11: 3482. https://doi.org/10.3390/jcm9113482

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