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Article

Characteristics and Prognosis of COVID-19 in Patients with COPD

1
Respiratory Medicine, University Hospital of Guadalajara, 19002 Guadalajara, Spain
2
Respiratory Medicine, Hospital Universitario de La Princesa, 28006 Madrid, Spain
3
Universidad Autónoma de Madrid, 28049 Madrid, Spain
4
Respiratory Diseases Networking Biomedical Research Centre (CIBERES), Institute of Health Carlos III (ISCIII), 28006 Madrid, Spain
5
SAVANA Medica, 28013 Madrid, Spain
6
Universidad Pontificia Comillas, 28015 Madrid, Spain
7
Department of Medicine and Medical Specialties, University of Alcalá, 28801 Madrid, Spain
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(10), 3259; https://doi.org/10.3390/jcm9103259
Received: 8 September 2020 / Revised: 26 September 2020 / Accepted: 6 October 2020 / Published: 12 October 2020
Patients with Chronic Obstructive Pulmonary Disease (COPD) have a higher prevalence of coronary ischemia and other factors that put them at risk for COVID-19-related complications. We aimed to explore the impact of COVID-19 in a large population-based sample of patients with COPD in Castilla-La Mancha, Spain. We analyzed clinical data in electronic health records from 1 January to 10 May 2020 by using Natural Language Processing through the SAVANA Manager® clinical platform. Out of 31,633 COPD patients, 793 had a diagnosis of COVID-19. The proportion of patients with COVID-19 in the COPD population (2.51%; 95% CI 2.33–2.68) was significantly higher than in the general population aged >40 years (1.16%; 95% CI 1.14–1.18); p < 0.001. Compared with COPD-free individuals, COPD patients with COVID-19 showed significantly poorer disease prognosis, as evaluated by hospitalizations (31.1% vs. 39.8%: OR 1.57; 95% CI 1.14–1.18) and mortality (3.4% vs. 9.3%: OR 2.93; 95% CI 2.27–3.79). Patients with COPD and COVID-19 were significantly older (75 vs. 66 years), predominantly male (83% vs. 17%), smoked more frequently, and had more comorbidities than their non-COPD counterparts. Pneumonia was the most common diagnosis among COPD patients hospitalized due to COVID-19 (59%); 19% of patients showed pulmonary infiltrates suggestive of pneumonia and heart failure. Mortality in COPD patients with COVID-19 was associated with older age and prevalence of heart failure (p < 0.05). COPD patients with COVID-19 showed higher rates of hospitalization and mortality, mainly associated with pneumonia. This clinical profile is different from exacerbations caused by other respiratory viruses in the winter season. View Full-Text
Keywords: COPD; COVID-19; prevalence; prognosis COPD; COVID-19; prevalence; prognosis
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MDPI and ACS Style

Graziani, D.; Soriano, J.B.; Del Rio-Bermudez, C.; Morena, D.; Díaz, T.; Castillo, M.; Alonso, M.; Ancochea, J.; Lumbreras, S.; Izquierdo, J.L. Characteristics and Prognosis of COVID-19 in Patients with COPD. J. Clin. Med. 2020, 9, 3259. https://doi.org/10.3390/jcm9103259

AMA Style

Graziani D, Soriano JB, Del Rio-Bermudez C, Morena D, Díaz T, Castillo M, Alonso M, Ancochea J, Lumbreras S, Izquierdo JL. Characteristics and Prognosis of COVID-19 in Patients with COPD. Journal of Clinical Medicine. 2020; 9(10):3259. https://doi.org/10.3390/jcm9103259

Chicago/Turabian Style

Graziani, Desirée, Joan B. Soriano, Carlos Del Rio-Bermudez, Diego Morena, Teresa Díaz, María Castillo, Miguel Alonso, Julio Ancochea, Sara Lumbreras, and José L. Izquierdo 2020. "Characteristics and Prognosis of COVID-19 in Patients with COPD" Journal of Clinical Medicine 9, no. 10: 3259. https://doi.org/10.3390/jcm9103259

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