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Association of Plasma Heat Shock Protein 70 with Disease Severity, Smoking and Lung Function of Patients with Chronic Obstructive Pulmonary Disease

Characteristics and Prognosis of COVID-19 in Patients with COPD

Respiratory Medicine, University Hospital of Guadalajara, 19002 Guadalajara, Spain
Respiratory Medicine, Hospital Universitario de La Princesa, 28006 Madrid, Spain
Universidad Autónoma de Madrid, 28049 Madrid, Spain
Respiratory Diseases Networking Biomedical Research Centre (CIBERES), Institute of Health Carlos III (ISCIII), 28006 Madrid, Spain
SAVANA Medica, 28013 Madrid, Spain
Universidad Pontificia Comillas, 28015 Madrid, Spain
Department of Medicine and Medical Specialties, University of Alcalá, 28801 Madrid, Spain
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(10), 3259;
Received: 8 September 2020 / Revised: 26 September 2020 / Accepted: 6 October 2020 / Published: 12 October 2020
Patients with Chronic Obstructive Pulmonary Disease (COPD) have a higher prevalence of coronary ischemia and other factors that put them at risk for COVID-19-related complications. We aimed to explore the impact of COVID-19 in a large population-based sample of patients with COPD in Castilla-La Mancha, Spain. We analyzed clinical data in electronic health records from 1 January to 10 May 2020 by using Natural Language Processing through the SAVANA Manager® clinical platform. Out of 31,633 COPD patients, 793 had a diagnosis of COVID-19. The proportion of patients with COVID-19 in the COPD population (2.51%; 95% CI 2.33–2.68) was significantly higher than in the general population aged >40 years (1.16%; 95% CI 1.14–1.18); p < 0.001. Compared with COPD-free individuals, COPD patients with COVID-19 showed significantly poorer disease prognosis, as evaluated by hospitalizations (31.1% vs. 39.8%: OR 1.57; 95% CI 1.14–1.18) and mortality (3.4% vs. 9.3%: OR 2.93; 95% CI 2.27–3.79). Patients with COPD and COVID-19 were significantly older (75 vs. 66 years), predominantly male (83% vs. 17%), smoked more frequently, and had more comorbidities than their non-COPD counterparts. Pneumonia was the most common diagnosis among COPD patients hospitalized due to COVID-19 (59%); 19% of patients showed pulmonary infiltrates suggestive of pneumonia and heart failure. Mortality in COPD patients with COVID-19 was associated with older age and prevalence of heart failure (p < 0.05). COPD patients with COVID-19 showed higher rates of hospitalization and mortality, mainly associated with pneumonia. This clinical profile is different from exacerbations caused by other respiratory viruses in the winter season. View Full-Text
Keywords: COPD; COVID-19; prevalence; prognosis COPD; COVID-19; prevalence; prognosis
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MDPI and ACS Style

Graziani, D.; Soriano, J.B.; Del Rio-Bermudez, C.; Morena, D.; Díaz, T.; Castillo, M.; Alonso, M.; Ancochea, J.; Lumbreras, S.; Izquierdo, J.L. Characteristics and Prognosis of COVID-19 in Patients with COPD. J. Clin. Med. 2020, 9, 3259.

AMA Style

Graziani D, Soriano JB, Del Rio-Bermudez C, Morena D, Díaz T, Castillo M, Alonso M, Ancochea J, Lumbreras S, Izquierdo JL. Characteristics and Prognosis of COVID-19 in Patients with COPD. Journal of Clinical Medicine. 2020; 9(10):3259.

Chicago/Turabian Style

Graziani, Desirée, Joan B Soriano, Carlos Del Rio-Bermudez, Diego Morena, Teresa Díaz, María Castillo, Miguel Alonso, Julio Ancochea, Sara Lumbreras, and José Luis Izquierdo. 2020. "Characteristics and Prognosis of COVID-19 in Patients with COPD" Journal of Clinical Medicine 9, no. 10: 3259.

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