Next Article in Journal
High-Intensity Interval Training Is Effective at Increasing Exercise Endurance Capacity and Is Well Tolerated by Adults with Cystic Fibrosis
Next Article in Special Issue
Characteristics and Prognosis of COVID-19 in Patients with COPD
Previous Article in Journal
Physicochemical and Antibacterial Properties of Novel, Premixed Calcium Silicate-Based Sealer Compared to Powder–Liquid Bioceramic Sealer
Previous Article in Special Issue
Integrating Comorbidities and Phenotype-Based Medicine in Patient-Centered Medicine in COPD
Article

Association of Plasma Heat Shock Protein 70 with Disease Severity, Smoking and Lung Function of Patients with Chronic Obstructive Pulmonary Disease

1
Department of Medical Biochemistry and Haematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia
2
Clinical Department for Lung Diseases Jordanovac, University Hospital Centre Zagreb, 10000 Zagreb, Croatia
3
School of Medicine, University of Zagreb, 10000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(10), 3097; https://doi.org/10.3390/jcm9103097
Received: 31 August 2020 / Revised: 17 September 2020 / Accepted: 23 September 2020 / Published: 25 September 2020
Extracellular heat shock protein 70 (eHsp70) might modulate immune responses in chronic obstructive pulmonary disease (COPD). The aim of the study was to explore eHsp70 concentration in stable COPD, its association with disease severity and smoking status as well as its diagnostic performance in COPD assessment. Plasma samples were collected from 137 COPD patients and 95 healthy individuals, and concentration of eHsp70 was assessed by commercially available enzyme-linked immunosorbent assay (ELISA) kit (Enzo Life Science, Farmingdale, NY, USA). COPD patients were subdivided regarding airflow obstruction severity and symptoms severity according to the Global Initiative for COPD (GOLD) guidelines. eHsp70 concentration increased in COPD patients when compared to controls and increased with the severity of airflow limitation as well as symptoms burden and exacerbation history. eHsp70 concentration did not differ among COPD patients based on smoking status, yet it increased in healthy smokers compared to healthy nonsmokers. In addition, eHsp70 negatively correlated with lung function parameters forced expiratory volume in one second (FEV1) and FEV1/ forced vital capacity (FVC), and positively with COPD multicomponent indices BODCAT (BMI, airflow obstruction, dyspnea, CAT score), BODEx (BMI, airflow obstruction, dyspnea, previous exacerbations), CODEx (Charlson’s comorbidity index, airflow obstruction, dyspnea, previous exacerbations) and DOSE (dyspnea, airflow obstruction, smoking status, previous exacerbations) With great predictive value (OR = 7.63) obtained from univariate logistic regression, eHsp70 correctly classified 76% of cases. eHsp70 is associated with COPD prediction and disease severity and might have the potential for becoming an additional biomarker in COPD assessment. View Full-Text
Keywords: chronic obstructive pulmonary disease; extracellular heat shock protein 70; smoking; lung function; EDTA plasma chronic obstructive pulmonary disease; extracellular heat shock protein 70; smoking; lung function; EDTA plasma
Show Figures

Figure 1

MDPI and ACS Style

Hlapčić, I.; Hulina-Tomašković, A.; Grdić Rajković, M.; Popović-Grle, S.; Vukić Dugac, A.; Rumora, L. Association of Plasma Heat Shock Protein 70 with Disease Severity, Smoking and Lung Function of Patients with Chronic Obstructive Pulmonary Disease. J. Clin. Med. 2020, 9, 3097. https://doi.org/10.3390/jcm9103097

AMA Style

Hlapčić I, Hulina-Tomašković A, Grdić Rajković M, Popović-Grle S, Vukić Dugac A, Rumora L. Association of Plasma Heat Shock Protein 70 with Disease Severity, Smoking and Lung Function of Patients with Chronic Obstructive Pulmonary Disease. Journal of Clinical Medicine. 2020; 9(10):3097. https://doi.org/10.3390/jcm9103097

Chicago/Turabian Style

Hlapčić, Iva, Andrea Hulina-Tomašković, Marija Grdić Rajković, Sanja Popović-Grle, Andrea Vukić Dugac, and Lada Rumora. 2020. "Association of Plasma Heat Shock Protein 70 with Disease Severity, Smoking and Lung Function of Patients with Chronic Obstructive Pulmonary Disease" Journal of Clinical Medicine 9, no. 10: 3097. https://doi.org/10.3390/jcm9103097

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop