SERS-Based Liquid Biopsy of Gastrointestinal Tumors Using a Portable Raman Device Operating in a Clinical Environment
Abstract
:1. Introduction
2. Experimental Section
2.1. Preparation of Human Serum Samples
2.2. SERS Measurements of Serum Samples
2.3. Statistical Analysis
3. Results
3.1. Discrimination between the GCRC and Ctrl Groups Based on SERS Data
3.2. Discrimination between the GCRC and Ctrl Groups Based on Inflammatory Markers
3.3. Discrimination between the GCRC and Ctrl Groups Based on SERS Data Combined with Blood Tests
3.4. PCA-QDA Model for Cancer Grading
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Avram, L.; Iancu, S.D.; Stefancu, A.; Moisoiu, V.; Colnita, A.; Marconi, D.; Donca, V.; Buzdugan, E.; Craciun, R.; Leopold, N.; et al. SERS-Based Liquid Biopsy of Gastrointestinal Tumors Using a Portable Raman Device Operating in a Clinical Environment. J. Clin. Med. 2020, 9, 212. https://doi.org/10.3390/jcm9010212
Avram L, Iancu SD, Stefancu A, Moisoiu V, Colnita A, Marconi D, Donca V, Buzdugan E, Craciun R, Leopold N, et al. SERS-Based Liquid Biopsy of Gastrointestinal Tumors Using a Portable Raman Device Operating in a Clinical Environment. Journal of Clinical Medicine. 2020; 9(1):212. https://doi.org/10.3390/jcm9010212
Chicago/Turabian StyleAvram, Lucretia, Stefania D. Iancu, Andrei Stefancu, Vlad Moisoiu, Alia Colnita, Daniel Marconi, Valer Donca, Elena Buzdugan, Rares Craciun, Nicolae Leopold, and et al. 2020. "SERS-Based Liquid Biopsy of Gastrointestinal Tumors Using a Portable Raman Device Operating in a Clinical Environment" Journal of Clinical Medicine 9, no. 1: 212. https://doi.org/10.3390/jcm9010212
APA StyleAvram, L., Iancu, S. D., Stefancu, A., Moisoiu, V., Colnita, A., Marconi, D., Donca, V., Buzdugan, E., Craciun, R., Leopold, N., Crisan, N., Coman, I., & Crisan, D. (2020). SERS-Based Liquid Biopsy of Gastrointestinal Tumors Using a Portable Raman Device Operating in a Clinical Environment. Journal of Clinical Medicine, 9(1), 212. https://doi.org/10.3390/jcm9010212