Next Article in Journal
Genetic Predispositions of Glucocorticoid Resistance and Therapeutic Outcomes in Polymyalgia Rheumatica and Giant Cell Arteritis
Next Article in Special Issue
Resting Heart Rate Variability Predicts Vulnerability to Pharmacologically-Induced Ventricular Arrhythmias in Male Rats
Previous Article in Journal
Incidental Finding of Strut Malapposition Is a Predictor of Late and Very Late Thrombosis in Coronary Bioresorbable Scaffolds
Previous Article in Special Issue
Cardiac and Peripheral Autonomic Responses to Orthostatic Stress During Transcutaneous Vagus Nerve Stimulation in Healthy Subjects
Open AccessArticle

Relevance of Targeting the Distal Renal Artery and Branches with Radiofrequency Renal Denervation Approaches—A Secondary Analysis from a Hypertensive CKD Patient Cohort

1
Dobney Hypertension Cenre, School of Medicine—Royal Perth Hospital Unit, Faculty of Medicine, Dentistry & Health Sciences, The University of Western Australia Level 3, MRF Building, Rear 50 Murray St, Perth WA 6000, MDBP: M570, Australia
2
Departments of Cardiology and Nephrology, Royal Perth Hospital, Perth WA 6000, Australia
3
Neurovascular Hypertension & Kidney Disease Laboratory, Baker Heart and Diabetes Institute, Melbourne VIC 3004, Australia
4
Cardioangiologisches Centrum Bethanien (CCB) Frankfurt am Main, Medizinische Klinik III, Agaplesion Markus Krankenhaus, Frankfurt am Main 60431, Germany
5
Cardiology Division, Department of Medicine, Universidade Federal Fluminense, Niterói, RJ 24033-900, Brazil
6
Nephrology Division, Department of Medicine, Universidade Federal Fluminense, Niterói, RJ 24033-900, Brazil
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(5), 581; https://doi.org/10.3390/jcm8050581
Received: 21 March 2019 / Revised: 24 April 2019 / Accepted: 25 April 2019 / Published: 27 April 2019
(This article belongs to the Special Issue Autonomic Nervous System: From Bench to Bedside)
We searched for an association between changes in blood pressure (BP) at 12 and 24 months after renal denervation (RDN) and the different patterns of ablation spots placement along the renal artery vasculature. We performed a post-hoc analysis of a 24-month follow-up evaluation of 30 patients who underwent RDN between 2011 and 2012 using our previous database. Patients who had (i) resistant hypertension, as meticulously described previously, and (ii) Chronic kidney disease (CKD) stages 2, 3 and 4. Correlations were assessed using the Pearson or Spearman correlation tests as appropriate. The mean change in systolic ambulatory BP monitoring (ABPM) compared to baseline was −19.4 ± 12.7 mmHg at the 12th (p < 0.0001) and −21.3 ± 14.1 mmHg at the 24th month (p < 0.0001). There was no correlation between the ABPM Systolic Blood Pressure (SBP)-lowering effect and the total number of ablated spots in renal arteries (17.7 ± 6.0) either at 12 (r = −0.3, p = 0.1542) or at 24 months (r = −0.2, p = 0.4009). However, correlations between systolic BP-lowering effect and the number of ablation spots performed in the distal segment and branches were significant at the 12 (r = −0.7, p < 0.0001) and 24 months (r = −0.8, p < 0.0001) follow-up. Our findings indicate a substantial correlation between the numbers of ablated sites in the distal segment and branches of renal arteries and the systolic BP-lowering effect in the long-term. View Full-Text
Keywords: hypertension; chronic kidney disease; renal denervation; blood pressure reduction; sympathetic nervous system hypertension; chronic kidney disease; renal denervation; blood pressure reduction; sympathetic nervous system
Show Figures

Figure 1

MDPI and ACS Style

Kiuchi, M.G.; Schlaich, M.P.; Chen, S.; Villacorta, H.; Ho, J.K.; Carnagarin, R.; Matthews, V.B.; Lugon, J.R. Relevance of Targeting the Distal Renal Artery and Branches with Radiofrequency Renal Denervation Approaches—A Secondary Analysis from a Hypertensive CKD Patient Cohort. J. Clin. Med. 2019, 8, 581.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop