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Open AccessArticle

Cell-Free Osteochondral Scaffold for the Treatment of Focal Articular Cartilage Defects in Early Knee OA: 5 Years’ Follow-Up Results

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Ortopedia Bentivoglio, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
2
Clinica Ortopedica e Traumatologica II, Applied Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
3
Clinica Ortopedica e Traumatologica II, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
4
Applied Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(11), 1978; https://doi.org/10.3390/jcm8111978
Received: 20 September 2019 / Revised: 4 November 2019 / Accepted: 13 November 2019 / Published: 14 November 2019
(This article belongs to the Special Issue Cartilage Repair and Restorative Procedures)
The purpose of this study was to investigate the clinical results at five years’ follow-up of a tri-layered nanostructured biomimetic osteochondral scaffold used for focal articular cartilage defects in patients meeting the criteria of early osteoarthritis (EOA). The study population comprised 22 patients (mean age: 39 years), prospectively assessed before surgery, at 24 and 60 months’ follow-up. Inclusion criteria were: at least two episodes of knee pain for more than 10 days in the last year, Kellgren-Lawrence OA grade 0, I or II and arthroscopic or MRI findings according to the European Society of Sports Traumatology, Knee Surgery & Arthroscopy (ESSKA) criteria. Clinical results demonstrated significant improvement in International Knee Documentation Committee (IKDC) subjective and objective scores and in Tegner score, although activity level never reached the pre-injury level. The complication rate of this study was 8.3%. Two patients underwent re-operation (8.3%), while a comprehensive definition of failure (including both surgical and clinical criteria) identified four failed patients (16.6%) at this mid-term follow-up evaluation. The use of a free-cell osteochondral scaffold represented a safe and valid alternative for the treatment of focal articular cartilage defects in the setting of an EOA, and was able to permit a significant clinical improvement and stable outcome with low complication and failure rates. View Full-Text
Keywords: early osteoarthritis; surgical treatment; knee; scaffold; osteochondral; cartilage early osteoarthritis; surgical treatment; knee; scaffold; osteochondral; cartilage
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MDPI and ACS Style

Sessa, A.; Andriolo, L.; Di Martino, A.; Romandini, I.; De Filippis, R.; Zaffagnini, S.; Filardo, G. Cell-Free Osteochondral Scaffold for the Treatment of Focal Articular Cartilage Defects in Early Knee OA: 5 Years’ Follow-Up Results. J. Clin. Med. 2019, 8, 1978. https://doi.org/10.3390/jcm8111978

AMA Style

Sessa A, Andriolo L, Di Martino A, Romandini I, De Filippis R, Zaffagnini S, Filardo G. Cell-Free Osteochondral Scaffold for the Treatment of Focal Articular Cartilage Defects in Early Knee OA: 5 Years’ Follow-Up Results. Journal of Clinical Medicine. 2019; 8(11):1978. https://doi.org/10.3390/jcm8111978

Chicago/Turabian Style

Sessa, Andrea; Andriolo, Luca; Di Martino, Alessandro; Romandini, Iacopo; De Filippis, Roberto; Zaffagnini, Stefano; Filardo, Giuseppe. 2019. "Cell-Free Osteochondral Scaffold for the Treatment of Focal Articular Cartilage Defects in Early Knee OA: 5 Years’ Follow-Up Results" J. Clin. Med. 8, no. 11: 1978. https://doi.org/10.3390/jcm8111978

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