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Small Bowel—Key Player in Health and Disease
Open AccessArticle

Cancer Risk in Collagenous Colitis

1
Department of Gastroenterology, Skåne University Hospital, 205 02 Malmö, Sweden
2
Centre for Liver & Digestive Disorders, the Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, Scotland, UK
3
Department of Laboratory Medicine, Division of Clinical Chemistry and Pharmacology, SUS, Lund University, 221 85 Lund, Sweden
4
Department of Medicine, Division of Gastroenterology, Örebro University Hospital, 702 81 Örebro, Sweden; School of Health and Medical Sciences, Örebro University, 701 85 Örebro, Sweden
5
Division of Gastroenterology and Hepatology, Department of Clinical and Experimental Medicine, Faculty of Health Science, Linköpings University, 581 83 Linköping, Sweden
6
Open University of Cyprus, Faculty of Economics and Management, 1678 Nicosia, Cyprus
7
Department of Medicine, Endoscopy Unit, Skåne University Hospital, 205 02 Malmö, Sweden
8
Pathology Department, Western General Hospital, Edinburgh EH4 2XU , Scotland, UK
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Clin. Med. 2019, 8(11), 1942; https://doi.org/10.3390/jcm8111942
Received: 5 September 2019 / Revised: 25 October 2019 / Accepted: 7 November 2019 / Published: 11 November 2019
(This article belongs to the Special Issue Diagnosis and Treatment of Small Bowel Disorders)
Data on malignancy in patients with collagenous colitis (CC) is scarce. We aimed to determine the incidence of cancers in patients with CC. In a two-stages, observational study, data on cancers in patients diagnosed with CC during 2000–2015, were collected from two cohorts. The risk was calculated according to the age-standardized rate for the first cohort and according to the standardized incidence ratio for the second cohort. The first cohort comprised 738 patients (394 from Scotland and 344 from Sweden; mean age 71 ± 11 and 66 ± 13 years, respectively). The incidence rates for lung cancer (RR 3.9, p = 0.001), bladder cancer (RR 9.2, p = 0.019), and non-melanoma skin cancer (NMSC) (RR 15, p = 0.001) were increased. As the majority of NMSC cases (15/16) came from Sweden, a second Swedish cohort, comprising 1141 patients (863 women, mean age 65 years, range 20–95 years) was collected. There were 93 cancer cases (besides NMSC). The risk for colon cancer was decreased (SIR 0.23, p= 0.0087). The risk for cutaneous squamous cell carcinoma was instead markedly increased (SIR 3.27, p = 0.001). View Full-Text
Keywords: colon cancer; cancer risk; collagenous colitis; lung cancer; microscopic colitis; skin cancer; squamous cell carcinoma colon cancer; cancer risk; collagenous colitis; lung cancer; microscopic colitis; skin cancer; squamous cell carcinoma
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MDPI and ACS Style

Larsson, J.K.; Dabos, K.J.; Höglund, P.; Bohr, J.; Münch, A.; Giannakou, A.; Nemeth, A.; Wurm-Johansson, G.; Toth, E.; Plevris, J.N.; Fineron, P.; Koulaouzidis, A.; Sjöberg, K. Cancer Risk in Collagenous Colitis. J. Clin. Med. 2019, 8, 1942. https://doi.org/10.3390/jcm8111942

AMA Style

Larsson JK, Dabos KJ, Höglund P, Bohr J, Münch A, Giannakou A, Nemeth A, Wurm-Johansson G, Toth E, Plevris JN, Fineron P, Koulaouzidis A, Sjöberg K. Cancer Risk in Collagenous Colitis. Journal of Clinical Medicine. 2019; 8(11):1942. https://doi.org/10.3390/jcm8111942

Chicago/Turabian Style

Larsson, Johanna K.; Dabos, Konstantinos J.; Höglund, Peter; Bohr, Johan; Münch, Andreas; Giannakou, Andry; Nemeth, Artur; Wurm-Johansson, Gabriele; Toth, Ervin; Plevris, John N.; Fineron, Paul; Koulaouzidis, Anastasios; Sjöberg, Klas. 2019. "Cancer Risk in Collagenous Colitis" J. Clin. Med. 8, no. 11: 1942. https://doi.org/10.3390/jcm8111942

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