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Article

The Effects of Postoperative Astaxanthin Administration on Nasal Mucosa Wound Healing

1
2nd Department of Otolaryngology, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania
2
Department of Experimental Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania
3
Pathology Department, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(11), 1941; https://doi.org/10.3390/jcm8111941
Received: 22 August 2019 / Revised: 6 November 2019 / Accepted: 8 November 2019 / Published: 11 November 2019
(This article belongs to the Special Issue Prevention, Diagnosis and Management of Chronic Rhinosinusitis)
Background: Wound healing of the nasal mucosa after endoscopic sinus surgery (ESS) is frequently complicated by scaring and consequently recurrences are encountered. Methods of optimizing results have been sought. In the present study we evaluated the effects of a powerful antioxidant, astaxanthin, on nasal mucosa healing after surgery, comparing it to the extensively studied properties of dexamethasone. Materials and Methods: 63 Wistar rats were used. The nasal mucosa from one side was damaged employing the brushing method. They were randomly divided into three experimental groups, one treated with astaxanthin, the second treated with dexamethasone and the third one acted as the control and was given normal saline. The rats were killed on days 5, 14 and 28 following injury. We observed the temporal evolution of the wound healing process and quantified the results by assessing four parameters: the epithelial thickness index (ETI), the subepithelial thickness index (STI), the goblet cell count and the subepithelial fibrosis index (SFI). Results: At 28 days, the ETI was significantly lower in the astaxanthin group (p < 0.05) compared to the other two groups. The STI was also lower in the astaxanthin group (p < 0.05), but comparable to the dexamethasone group at 28 days. The goblet cell count was higher in the astaxanthin group. The SFI had similar results in both dexamethasone and astaxanthin groups, with lower values compared to the control group. In the astaxanthin group there was no synechia formation. Conclusion: Astaxanthin given in the post injury period significantly decreases fibrosis, inhibits synechia development and significantly decreases subepithelial fibrosis. Moreover, it has no general or local toxic effects. View Full-Text
Keywords: nasal mucosa healing; astaxanthin; dexamethasone; synechia; epithelial thickness; subepithelial thickness; subepithelial fibrosis nasal mucosa healing; astaxanthin; dexamethasone; synechia; epithelial thickness; subepithelial thickness; subepithelial fibrosis
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MDPI and ACS Style

Manciula, L.-G.; Berce, C.; Tabaran, F.; Trombitaș, V.; Albu, S. The Effects of Postoperative Astaxanthin Administration on Nasal Mucosa Wound Healing. J. Clin. Med. 2019, 8, 1941. https://doi.org/10.3390/jcm8111941

AMA Style

Manciula L-G, Berce C, Tabaran F, Trombitaș V, Albu S. The Effects of Postoperative Astaxanthin Administration on Nasal Mucosa Wound Healing. Journal of Clinical Medicine. 2019; 8(11):1941. https://doi.org/10.3390/jcm8111941

Chicago/Turabian Style

Manciula, Lavinia-Gianina, Cristian Berce, Flaviu Tabaran, Veronica Trombitaș, and Silviu Albu. 2019. "The Effects of Postoperative Astaxanthin Administration on Nasal Mucosa Wound Healing" Journal of Clinical Medicine 8, no. 11: 1941. https://doi.org/10.3390/jcm8111941

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