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Open AccessArticle

Perinatal Outcome and Long-Term Gastrointestinal Morbidity of Offspring of Women with Celiac Disease

1
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel
2
Faculty of Health Sciences, Ben-Gurion University of the Negev, School of Public Health, Beer-Sheva 8410501, Israel
*
Author to whom correspondence should be addressed.
They declare the equally contributed.
J. Clin. Med. 2019, 8(11), 1924; https://doi.org/10.3390/jcm8111924
Received: 28 September 2019 / Revised: 13 October 2019 / Accepted: 6 November 2019 / Published: 8 November 2019
(This article belongs to the Section Obstetrics & Gynecology)
The aim of this study was to evaluate perinatal outcome and long-term offspring gastrointestinal morbidity of women with celiac disease. Perinatal outcomes, as well as long-term gastrointestinal morbidity of offspring of mothers with and without celiac disease were assessed. The study groups were followed until 18 years of age for gastrointestinal-related morbidity. For perinatal outcomes, generalized estimation equation (GEE) models were used. A Kaplan–Meier survival curve was used to compare cumulative incidence of long-term gastrointestinal morbidity, and Cox proportional hazards models were constructed to control for confounders. During the study period, 243,682 deliveries met the inclusion criteria, of which 212 (0.08%) were to mothers with celiac disease. Using GEE models, maternal celiac disease was noted as an independent risk factor for low birth weight and cesarean delivery. Offspring born to mothers with celiac disease had higher rates of gastrointestinal related morbidity (Kaplan–Meier log rank test P < 0.001). Using a Cox proportional hazards model, being born to a mother with celiac disease was found to be an independent risk factor for long-term gastrointestinal morbidity of the offspring. Pregnancy of women with celiac disease is independently associated with adverse perinatal outcome as well as higher risk for long-term gastrointestinal morbidity of offspring.
Keywords: celiac; gastrointestinal morbidity; long term; maternal celiac; offspring celiac; gastrointestinal morbidity; long term; maternal celiac; offspring
MDPI and ACS Style

Abecassis, A.; Wainstock, T.; Sheiner, E.; Pariente, G. Perinatal Outcome and Long-Term Gastrointestinal Morbidity of Offspring of Women with Celiac Disease. J. Clin. Med. 2019, 8, 1924.

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