Next Article in Journal
Health Behavior and Health and Psychosocial Planning for Retirement among Spanish Health Professionals
Next Article in Special Issue
The Emerging Role of Neutrophil Granulocytes in Multiple Sclerosis
Previous Article in Journal
The Number of Comorbidities Predicts Renal Outcomes in Patients with Stage 3–5 Chronic Kidney Disease
Previous Article in Special Issue
PLP1 Mutations in Patients with Multiple Sclerosis: Identification of a New Mutation and Potential Pathogenicity of the Mutations
Open AccessReview

The Short and Long-Term Effects of Pregnancy on Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

The University of Queensland, Centre for Clinical Research, Brisbane, QLD 4029, Australia
J. Clin. Med. 2018, 7(12), 494; https://doi.org/10.3390/jcm7120494
Received: 1 October 2018 / Revised: 21 November 2018 / Accepted: 21 November 2018 / Published: 28 November 2018
(This article belongs to the Special Issue Potential Pathogenic Mechanisms of Multiple Sclerosis)
The role of pregnancy in multiple sclerosis (MS) is of importance because many patients with MS are young women in the childbearing age who require information to inform their reproductive decisions. Pregnancy is now well-known to be associated with fewer relapses of MS and reduced activity of autoimmune encephalomyelitis (EAE). However, in women with multiple sclerosis, this benefit is not always sufficient to protect against a rebound of disease activity if disease-modulating therapy is ceased for pregnancy. There is concern that use of assisted reproductive therapies can be associated with relapses of MS, but more data are required. It is thought that the beneficial effects of pregnancy are due to the pregnancy-associated changes in the maternal immune system. There is some evidence of this in human studies and studies of EAE. There is also evidence that having been pregnant leads to better long-term outcome of MS. The mechanism for this is not fully understood but it could result from epigenetic changes resulting from pregnancy or parenthood. Further studies of the mechanisms of the beneficial effects of pregnancy could provide information that might be used to produce new therapies. View Full-Text
Keywords: multiple sclerosis; pregnancy; experimental autoimmune encephalomyeltis; epigenetics multiple sclerosis; pregnancy; experimental autoimmune encephalomyeltis; epigenetics
MDPI and ACS Style

McCombe, P.A. The Short and Long-Term Effects of Pregnancy on Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. J. Clin. Med. 2018, 7, 494.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

1
Back to TopTop