Next Article in Journal
Minimal Residual Disease in Acute Myeloid Leukemia: Still a Work in Progress?
Next Article in Special Issue
An Effective, Versatile, and Inexpensive Device for Oxygen Uptake Measurement
Previous Article in Journal
The Role of Interleukin-18, Oxidative Stress and Metabolic Syndrome in Alzheimer’s Disease
Previous Article in Special Issue
Riboflavin Responsive Mitochondrial Dysfunction in Neurodegenerative Diseases
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessFeature PaperReview
J. Clin. Med. 2017, 6(6), 56;

Use of the Ketogenic Diet to Treat Intractable Epilepsy in Mitochondrial Disorders

Chelsea and Westmister Hospital, 369 Fulham road, Chelsea, London SW10 9NH, UK
Author to whom correspondence should be addressed.
Academic Editor: Iain P. Hargreaves
Received: 31 March 2017 / Revised: 16 May 2017 / Accepted: 22 May 2017 / Published: 26 May 2017
Full-Text   |   PDF [870 KB, uploaded 2 June 2017]   |  


Mitochondrial disorders are a clinically heterogeneous group of disorders that are caused by defects in the respiratory chain, the metabolic pathway of the adenosine tri-phosphate (ATP) production system. Epilepsy is a common and important feature of these disorders and its management can be challenging. Epileptic seizures in the context of mitochondrial disease are usually treated with conventional anti-epileptic medication, apart from valproic acid. However, in accordance with the treatment of intractable epilepsy where there are limited treatment options, the ketogenic diet (KD) has been considered as an alternative therapy. The use of the KD and its more palatable formulations has shown promising results. It is especially indicated and effective in the treatment of mitochondrial disorders due to complex I deficiency. Further research into the mechanism of action and the neuroprotective properties of the KD will allow more targeted therapeutic strategies and thus optimize the treatment of both epilepsy in the context of mitochondrial disorders but also in other neurodegenerative disorders. View Full-Text
Keywords: ketogenic diet; mitochondrial disorders; intractable epilepsy; treatment ketogenic diet; mitochondrial disorders; intractable epilepsy; treatment

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Printed Edition Available!
A printed edition of this Special Issue is available here.

Share & Cite This Article

MDPI and ACS Style

Paleologou, E.; Ismayilova, N.; Kinali, M. Use of the Ketogenic Diet to Treat Intractable Epilepsy in Mitochondrial Disorders. J. Clin. Med. 2017, 6, 56.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top