Next Article in Journal
Minimal Residual Disease in Acute Myeloid Leukemia: Still a Work in Progress?
Next Article in Special Issue
An Effective, Versatile, and Inexpensive Device for Oxygen Uptake Measurement
Previous Article in Journal
The Role of Interleukin-18, Oxidative Stress and Metabolic Syndrome in Alzheimer’s Disease
Previous Article in Special Issue
Riboflavin Responsive Mitochondrial Dysfunction in Neurodegenerative Diseases
Open AccessFeature PaperReview

Use of the Ketogenic Diet to Treat Intractable Epilepsy in Mitochondrial Disorders

Chelsea and Westmister Hospital, 369 Fulham road, Chelsea, London SW10 9NH, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Iain P. Hargreaves
J. Clin. Med. 2017, 6(6), 56; https://doi.org/10.3390/jcm6060056
Received: 31 March 2017 / Revised: 16 May 2017 / Accepted: 22 May 2017 / Published: 26 May 2017
Mitochondrial disorders are a clinically heterogeneous group of disorders that are caused by defects in the respiratory chain, the metabolic pathway of the adenosine tri-phosphate (ATP) production system. Epilepsy is a common and important feature of these disorders and its management can be challenging. Epileptic seizures in the context of mitochondrial disease are usually treated with conventional anti-epileptic medication, apart from valproic acid. However, in accordance with the treatment of intractable epilepsy where there are limited treatment options, the ketogenic diet (KD) has been considered as an alternative therapy. The use of the KD and its more palatable formulations has shown promising results. It is especially indicated and effective in the treatment of mitochondrial disorders due to complex I deficiency. Further research into the mechanism of action and the neuroprotective properties of the KD will allow more targeted therapeutic strategies and thus optimize the treatment of both epilepsy in the context of mitochondrial disorders but also in other neurodegenerative disorders. View Full-Text
Keywords: ketogenic diet; mitochondrial disorders; intractable epilepsy; treatment ketogenic diet; mitochondrial disorders; intractable epilepsy; treatment
Show Figures

Graphical abstract

MDPI and ACS Style

Paleologou, E.; Ismayilova, N.; Kinali, M. Use of the Ketogenic Diet to Treat Intractable Epilepsy in Mitochondrial Disorders. J. Clin. Med. 2017, 6, 56.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop