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Platypnea–Orthodeoxia Syndrome: Multiple Pathophysiological Interpretations of a Clinical Picture Primarily Consisting of Orthostatic Dyspnea

1
Cardiology Unit, Presidio Sanitario Intermedio “Elena d’Aosta”, ASL Napoli 1 Centro, 80137 Napoli, Italy
2
Heart Department, Interventional Cardiology, Azienda Ospedaliero-Universitaria “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Jane Grant-Kels
J. Clin. Med. 2016, 5(10), 85; https://doi.org/10.3390/jcm5100085
Received: 3 August 2016 / Revised: 8 September 2016 / Accepted: 21 September 2016 / Published: 23 September 2016
Platypnea–orthodexia syndrome (POS) is often a challenging diagnostic problem. It is characterized by dyspnea that is accentuated by standing or sitting positions due to a marked fall in blood oxygen saturation, and instead is improved by assuming the lying position. In the present brief review, the authors address the pathophysiology of POS, and outline its clinical symptoms as well as the main modalities of diagnostic evaluation and possible therapeutic options. Moreover, some problems concerning much-debated issues and persistent uncertainties about the pathophysiology of POS are presented along with the description of the diagnostic and therapeutic resources currently available for this syndrome. View Full-Text
Keywords: platypnea; intracardiac shunts; ventilation/perfusion mismatch; pulmonary arteriovenous shunts platypnea; intracardiac shunts; ventilation/perfusion mismatch; pulmonary arteriovenous shunts
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De Vecchis, R.; Baldi, C.; Ariano, C. Platypnea–Orthodeoxia Syndrome: Multiple Pathophysiological Interpretations of a Clinical Picture Primarily Consisting of Orthostatic Dyspnea. J. Clin. Med. 2016, 5, 85.

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