Next Article in Journal
Novel Compound Heterozygous Mutation of the ABCA3 Gene in a Patient with Neonatal-Onset Interstitial Lung Disease
Previous Article in Journal
Oral Bisphosphonates for Colorectal Cancer Prevention: A Meta-Analytic Reappraisal Beyond Bone Health
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Systematic Review

Myopericytoma Masquerading as Dupuytren’s Disease: A Case Report and Systematic Literature Review

1
Department of Plastic and Reconstructive Surgery, University of Siena, 53100 Siena, Italy
2
Faculty of Medicine and Surgery, Peninsula Clinical School, Monash University, Clayton, VIC 3199, Australia
3
Department of Plastic and Reconstructive Surgery, Peninsula Health, Frankston, Melbourne, VIC 3199, Australia
4
Faculty of Medicine and Surgery, Notre Dame University, Notre Dame, NSW 2002, Australia
5
Department of Orthopaedic Surgery, Royal Perth Hospital, Perth, WA 6000, Australia
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2025, 14(11), 3703; https://doi.org/10.3390/jcm14113703
Submission received: 15 April 2025 / Revised: 17 May 2025 / Accepted: 23 May 2025 / Published: 25 May 2025

Abstract

Background: Myopericytoma is a rare benign vascular tumour characterised by concentric spindle cell proliferation around blood vessels, often misdiagnosed due to its resemblance to other soft tissue masses. Dupuytren’s disease (DD), a fibroproliferative disorder of the palmar fascia, causes progressive contractures, typically affecting the ring and little fingers. While these conditions are well-documented individually, their coexistence in the same region is rare and diagnostically challenging. Case Presentation: This report highlights a 67-year-old male with longstanding DD and a recurrent palmar mass initially attributed to fibrosis. Magnetic resonance imaging revealed hallmark vascular features suggestive of myopericytoma, confirmed by histopathological analysis showing spindle cell proliferation and immunohistochemical positivity for alpha-smooth muscle actin and h-caldesmon. Concurrent DD, characterised by fibrosis and activated myofibroblasts, further complicated the clinical picture. Methodology: PubMed, Scopus, Web of Science, and Embase databases were searched from January 1901 to December 2024, and 20 studies were found, reporting 41 cases of myopericytoma in hand and upper extremity. Histopathological analysis consistently showed spindle cell proliferation and smooth muscle actin positivity. Coexistence with DD was rare, highlighting the need for detailed imaging and histological evaluation for accurate diagnosis. Conclusions: This case emphasises the complexity of differentiating overlapping pathologies. Surgical excision of myopericytoma and tailored DD management yielded favourable outcomes. Further research into shared fibroinflammatory pathways, including tumour necrosis factor-alpha and interleukin-6, may enhance diagnostic accuracy and treatment strategies for overlapping conditions.
Keywords: myopericytoma; Dupuytren’s disease; vascular tumour; fibroinflammatory pathways; histopathology; case report; systematic review myopericytoma; Dupuytren’s disease; vascular tumour; fibroinflammatory pathways; histopathology; case report; systematic review

Share and Cite

MDPI and ACS Style

Marcaccini, G.; Seth, I.; Novo, J.; Bautista, M.; Ruhunage, L.; Bhat, S.; Cuomo, R.; Rozen, W.M. Myopericytoma Masquerading as Dupuytren’s Disease: A Case Report and Systematic Literature Review. J. Clin. Med. 2025, 14, 3703. https://doi.org/10.3390/jcm14113703

AMA Style

Marcaccini G, Seth I, Novo J, Bautista M, Ruhunage L, Bhat S, Cuomo R, Rozen WM. Myopericytoma Masquerading as Dupuytren’s Disease: A Case Report and Systematic Literature Review. Journal of Clinical Medicine. 2025; 14(11):3703. https://doi.org/10.3390/jcm14113703

Chicago/Turabian Style

Marcaccini, Gianluca, Ishith Seth, Jennifer Novo, Marcus Bautista, Lakal Ruhunage, Saiuj Bhat, Roberto Cuomo, and Warren M. Rozen. 2025. "Myopericytoma Masquerading as Dupuytren’s Disease: A Case Report and Systematic Literature Review" Journal of Clinical Medicine 14, no. 11: 3703. https://doi.org/10.3390/jcm14113703

APA Style

Marcaccini, G., Seth, I., Novo, J., Bautista, M., Ruhunage, L., Bhat, S., Cuomo, R., & Rozen, W. M. (2025). Myopericytoma Masquerading as Dupuytren’s Disease: A Case Report and Systematic Literature Review. Journal of Clinical Medicine, 14(11), 3703. https://doi.org/10.3390/jcm14113703

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop