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Article

Weight Gain in Overweight and Obese People with HIV—The OBHIV Cohort

by
Lucia Taramasso
1,*,
Silvia Dettori
2,
Elena Ricci
3,
Sonia Lerta
2,
Sara Mora
4,
Sabrina Blanchi
1,
Mauro Giacomini
4,
Antonio Vena
1,2,
Matteo Bassetti
1,2 and
Antonio Di Biagio
1,2
1
Infectious Disease Clinic, IRCCS Policlinico San Martino Hospital, 16132 Genoa, Italy
2
Department of Health Sciences, Infectious Disease Clinic, University of Genoa, 16126 Genoa, Italy
3
Fondazione ASIA Onlus, Buccinasco, 20090 Milan, Italy
4
Department of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genoa, 16126 Genoa, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(5), 1211; https://doi.org/10.3390/jcm13051211
Submission received: 8 January 2024 / Revised: 7 February 2024 / Accepted: 15 February 2024 / Published: 21 February 2024
(This article belongs to the Section Infectious Diseases)
Versions Notes

Abstract

Background: HIV and non-HIV-related factors have been related to weight gain (WG); however, their specific impact on people with HIV (PWH) who are overweight or obese remains unclear. Methods: This is a single-center observational study enrolling PWH with a BMI > 25 kg/m2. A generalized linear model was used to assess variables related to greater WG during 12 years of observation. Results: A total of 321 PWH were enrolled, 67% overweight and 33% obese, who gained an average of 0.2 ± 1.3 and 1.7 ± 1.5 kg/year, respectively (p < 0.0001). Years since HIV infection were the only variable significantly associated with WG (β −0.048, 95% CI −0.083; −0.013) during the study period, while type of ART did not influence the outcome. Narrowing the observation to the period of the SARS-CoV-2 pandemic, PWH with a longer duration of infection (β 0.075, 95% CI 0.033; 0.117) and a greater increase in triglycerides (β 0.005; 95% CI 0.000; 0.011) gained more weight, while higher BMI (β −0.256, 95% CI −0.352; −0.160), obesity (β −1.363, 95% CI −2.319; −0.408), diabetes mellitus (β −1.538, 95% CI −2.797; −0.278), and greater abdominal circumference (β −0.086, 95% CI −0.142; −0.030) resulted in protection. Conclusion: Among overweight and obese PWH, the amount of WG was higher in the first years after diagnosis of HIV and decreased thereafter, despite aging, regardless of the type of ART.
Keywords: obese; overweight; OBHIV; weight gain; ART; comorbidities obese; overweight; OBHIV; weight gain; ART; comorbidities

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MDPI and ACS Style

Taramasso, L.; Dettori, S.; Ricci, E.; Lerta, S.; Mora, S.; Blanchi, S.; Giacomini, M.; Vena, A.; Bassetti, M.; Di Biagio, A. Weight Gain in Overweight and Obese People with HIV—The OBHIV Cohort. J. Clin. Med. 2024, 13, 1211. https://doi.org/10.3390/jcm13051211

AMA Style

Taramasso L, Dettori S, Ricci E, Lerta S, Mora S, Blanchi S, Giacomini M, Vena A, Bassetti M, Di Biagio A. Weight Gain in Overweight and Obese People with HIV—The OBHIV Cohort. Journal of Clinical Medicine. 2024; 13(5):1211. https://doi.org/10.3390/jcm13051211

Chicago/Turabian Style

Taramasso, Lucia, Silvia Dettori, Elena Ricci, Sonia Lerta, Sara Mora, Sabrina Blanchi, Mauro Giacomini, Antonio Vena, Matteo Bassetti, and Antonio Di Biagio. 2024. "Weight Gain in Overweight and Obese People with HIV—The OBHIV Cohort" Journal of Clinical Medicine 13, no. 5: 1211. https://doi.org/10.3390/jcm13051211

APA Style

Taramasso, L., Dettori, S., Ricci, E., Lerta, S., Mora, S., Blanchi, S., Giacomini, M., Vena, A., Bassetti, M., & Di Biagio, A. (2024). Weight Gain in Overweight and Obese People with HIV—The OBHIV Cohort. Journal of Clinical Medicine, 13(5), 1211. https://doi.org/10.3390/jcm13051211

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