The Clinical Characteristics and Outcomes of Acute Pancreatitis Are Different in Elderly Patients: A Single-Center Study over a 6-Year Period

Zhang, Shihang; Chen, Zhiyao; Hu, Cheng; Zhu, Ping; Jin, Tao; Li, Lan; Lin, Ziqi; Shi, Na; Zhang, Xiaoxin; Xia, Qing; Deng, Lihui

doi:10.3390/jcm13164829

Open AccessArticle

The Clinical Characteristics and Outcomes of Acute Pancreatitis Are Different in Elderly Patients: A Single-Center Study over a 6-Year Period

by

Shihang Zhang

^†,

Zhiyao Chen

^†,

Cheng Hu

,

Ping Zhu

,

Tao Jin

,

Lan Li

,

Ziqi Lin

,

Na Shi

,

Xiaoxin Zhang

,

Qing Xia

^* and

Lihui Deng

^*

West China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

J. Clin. Med. 2024, 13(16), 4829; https://doi.org/10.3390/jcm13164829

Submission received: 17 June 2024 / Revised: 4 August 2024 / Accepted: 14 August 2024 / Published: 16 August 2024

(This article belongs to the Special Issue Clinical Diagnosis and Treatment of Pancreatitis)

Download

Browse Figures

Versions Notes

Abstract

Objectives: This study aims to analyze the clinical characteristics of elderly patients with acute pancreatitis (AP) and investigate the effects of age on the clinical outcomes of AP. Methods: Patients aged ≥ 18 years with AP admitted within 72 h from 1 September 2013 to 31 August 2019 were included. Patients were divided into elderly (≥60 years) and non-elderly (<60 years) groups. Clinical data and outcomes were compared. Results: A total of 756 elderly and 4896 non-elderly patients with AP were included. The elderly patients had different etiological distributions and more severe clinical markers and scores. Age was an independent risk factor for mortality [odds ratio (OR): 2.911, 95% CI: 1.801–4.706, p < 0.001], intensive care unit admission (OR: 1.739, 95% CI: 1.126–2.685, p = 0.013), persistent organ failure (OR: 1.623, 95% CI: 1.326–1.987, p < 0.001), multiple organ failure (OR: 1.757, 95% CI: 1.186–2.604, p = 0.005), and infection (OR: 2.451, 95% CI: 1.994–3.013, p < 0.001). Adjusted multiple logistic regression and trend analysis confirmed the risk of the age for the outcomes. The deaths of elderly patients showed a biphasic pattern with peaks in the first and fifth weeks, in contrast to the single peak in the first week in the non-elderly patients. Conclusions: Elderly patients with AP were associated with worse clinical outcomes. It is crucial to devote considerable attention to the optimization of therapeutic approaches to reduce late mortality in this group of patients.

Keywords: acute pancreatitis; elderly; clinical characteristics; outcomes

Share and Cite

MDPI and ACS Style

Zhang, S.; Chen, Z.; Hu, C.; Zhu, P.; Jin, T.; Li, L.; Lin, Z.; Shi, N.; Zhang, X.; Xia, Q.; et al. The Clinical Characteristics and Outcomes of Acute Pancreatitis Are Different in Elderly Patients: A Single-Center Study over a 6-Year Period. J. Clin. Med. 2024, 13, 4829. https://doi.org/10.3390/jcm13164829

AMA Style

Zhang S, Chen Z, Hu C, Zhu P, Jin T, Li L, Lin Z, Shi N, Zhang X, Xia Q, et al. The Clinical Characteristics and Outcomes of Acute Pancreatitis Are Different in Elderly Patients: A Single-Center Study over a 6-Year Period. Journal of Clinical Medicine. 2024; 13(16):4829. https://doi.org/10.3390/jcm13164829

Chicago/Turabian Style

Zhang, Shihang, Zhiyao Chen, Cheng Hu, Ping Zhu, Tao Jin, Lan Li, Ziqi Lin, Na Shi, Xiaoxin Zhang, Qing Xia, and et al. 2024. "The Clinical Characteristics and Outcomes of Acute Pancreatitis Are Different in Elderly Patients: A Single-Center Study over a 6-Year Period" Journal of Clinical Medicine 13, no. 16: 4829. https://doi.org/10.3390/jcm13164829

APA Style

Zhang, S., Chen, Z., Hu, C., Zhu, P., Jin, T., Li, L., Lin, Z., Shi, N., Zhang, X., Xia, Q., & Deng, L. (2024). The Clinical Characteristics and Outcomes of Acute Pancreatitis Are Different in Elderly Patients: A Single-Center Study over a 6-Year Period. Journal of Clinical Medicine, 13(16), 4829. https://doi.org/10.3390/jcm13164829

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

The Clinical Characteristics and Outcomes of Acute Pancreatitis Are Different in Elderly Patients: A Single-Center Study over a 6-Year Period

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI