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Article

Platelet Rich Plasma Injections for Knee Osteoarthritis Treatment: A Prospective Clinical Study

1
Orthopaedic & Trauma Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, School of Medicine, University of Bari Aldo Moro, AOU Consorziale Policlinico, 70124 Bari, Italy
2
Orthopaedics Unit, Department of Clinical and Experimental Medicine, Faculty of Medicine and Surgery, University of Foggia, Policlinico Riuniti di Foggia, 71122 Foggia, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Yoshitomo Saita
J. Clin. Med. 2022, 11(9), 2640; https://doi.org/10.3390/jcm11092640
Received: 16 April 2022 / Revised: 3 May 2022 / Accepted: 6 May 2022 / Published: 8 May 2022
(This article belongs to the Special Issue Strategies for the Prevention of Knee Osteoarthritis)
Background: The aim of this prospective study was to evaluate the efficacy and safety of Platelet Rich Plasma (PRP) injections in patients affected by knee osteoarthritis (KOA). An autologous blood product containing a high percentage of various growth factors (GFs), cytokines and modulating factors as PRP has shown promising results in achieving this goal. Methods: One hundred and fifty-three patients (72 males, mean age 59.06 ± 8.78, range 40–81 years old) from January 2018 to January 2020 received three consecutive PRP injections and completed the follow ups. Western Ontario and McMaster University Osteoarthritis index (WOMAC), Knee society score (KSS) and Visual Analogic Scale (VAS) were evaluated before PRP injection (T0), one month (T1), three months (T2) and six months (T3) after the treatment. All patients underwent baseline and at 6 months MRI and X-ray evaluation. Results: A statistically significant VAS, KSS and WOMAC reduction emerged in the comparison between evaluations (p < 0.05), MRI demonstrated non-statistically significant improvement in cartilage thickness for both tibial plate and femoral plate (p = 0.46 and p = 0.33 respectively), and no radiographic changes could be seen in any patients. Conclusions: PRP injection represents a valid conservative treatment to reduce pain, improve quality of life and functional scores even at midterm of 6 months follow-up. View Full-Text
Keywords: knee osteoarthritis (KOA); cartilage; plateled riched plasma (PRP); knee injection; biologic therapy knee osteoarthritis (KOA); cartilage; plateled riched plasma (PRP); knee injection; biologic therapy
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MDPI and ACS Style

Moretti, L.; Maccagnano, G.; Coviello, M.; Cassano, G.D.; Franchini, A.; Laneve, A.; Moretti, B. Platelet Rich Plasma Injections for Knee Osteoarthritis Treatment: A Prospective Clinical Study. J. Clin. Med. 2022, 11, 2640. https://doi.org/10.3390/jcm11092640

AMA Style

Moretti L, Maccagnano G, Coviello M, Cassano GD, Franchini A, Laneve A, Moretti B. Platelet Rich Plasma Injections for Knee Osteoarthritis Treatment: A Prospective Clinical Study. Journal of Clinical Medicine. 2022; 11(9):2640. https://doi.org/10.3390/jcm11092640

Chicago/Turabian Style

Moretti, Lorenzo, Giuseppe Maccagnano, Michele Coviello, Giuseppe D. Cassano, Andrea Franchini, Andrea Laneve, and Biagio Moretti. 2022. "Platelet Rich Plasma Injections for Knee Osteoarthritis Treatment: A Prospective Clinical Study" Journal of Clinical Medicine 11, no. 9: 2640. https://doi.org/10.3390/jcm11092640

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