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Article

Feasibility Trial to Evaluate Tendon Stiffness Obtained from Shear Wave Elastography Imaging as a Biomarker of Aromatase Inhibitor-Induced Arthralgias

1
The University of Arizona Cancer Center, Tucson, AZ 85719, USA
2
Department of Nutritional Sciences, University of Arizona, Tucson, AZ 85719, USA
3
Department of Medical Imaging and Orthopaedic Surgery, University of Arizona, Tucson, AZ 85719, USA
4
Department of Radiology, University of New Mexico, Albuquerque, NM 87131, USA
5
Department of Biomedical Engineering, University of Arizona, Tucson, AZ 85719, USA
6
Department of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ 85719, USA
7
Department of Medicine, University of Arizona, Tucson, AZ 85719, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Kevin L. Garvin
J. Clin. Med. 2022, 11(4), 1067; https://doi.org/10.3390/jcm11041067
Received: 7 January 2022 / Revised: 12 February 2022 / Accepted: 16 February 2022 / Published: 18 February 2022
(This article belongs to the Special Issue Diagnostic Imaging of Arthritis)
Aromatase inhibitor-induced arthralgia (AIA) comprises significant, activity-limiting musculoskeletal symptoms, including joint pain, myalgia, and joint stiffness. We conducted a prospective feasibility study in postmenopausal women diagnosed with early-stage (0–3) hormone receptor positive (HR+) breast cancer who were candidates for treatment with adjuvant AI therapy (n = 16). Tendons of the hands and wrists and the median nerve were imaged using gray-scale and power Doppler ultrasound (US) and US SWE. Arthralgia symptoms were evaluated using the Breast Cancer Prevention Trial (BCPT) Symptom Checklist musculoskeletal subscale (MS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and stiffness subscales. At baseline, there were significant differences in the SW velocities of tendons between dominant and nondominant hands. Increased velocity in 2 of 6 tendons and the median nerve was associated with greater pain at baseline, whereas slower velocity of the extensor digitorum tendon (suggesting decreased stiffness) was associated with a higher WOMAC stiffness score. Increased SW velocity (suggestive of increased stiffness) at baseline in the abductor pollicis longus tendon was associated with a worsening of all three pain and stiffness measures by 6 months. Future studies should evaluate SWE scores related to AIA outcomes in a larger sample size. View Full-Text
Keywords: aromatase inhibitors; breast cancer; shear wave elastography; ultrasound; joint pain; stiffness; arthralgia; aromatase inhibitor–induced arthralgia (AIA) aromatase inhibitors; breast cancer; shear wave elastography; ultrasound; joint pain; stiffness; arthralgia; aromatase inhibitor–induced arthralgia (AIA)
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MDPI and ACS Style

Martinez, J.A.; Taljanovic, M.S.; Nuncio Zuniga, A.A.; Wertheim, B.C.; Roe, D.J.; Ehsani, S.; Jiralerspong, S.; Segar, J.; Chalasani, P. Feasibility Trial to Evaluate Tendon Stiffness Obtained from Shear Wave Elastography Imaging as a Biomarker of Aromatase Inhibitor-Induced Arthralgias. J. Clin. Med. 2022, 11, 1067. https://doi.org/10.3390/jcm11041067

AMA Style

Martinez JA, Taljanovic MS, Nuncio Zuniga AA, Wertheim BC, Roe DJ, Ehsani S, Jiralerspong S, Segar J, Chalasani P. Feasibility Trial to Evaluate Tendon Stiffness Obtained from Shear Wave Elastography Imaging as a Biomarker of Aromatase Inhibitor-Induced Arthralgias. Journal of Clinical Medicine. 2022; 11(4):1067. https://doi.org/10.3390/jcm11041067

Chicago/Turabian Style

Martinez, Jessica A., Mihra S. Taljanovic, Andres A. Nuncio Zuniga, Betsy C. Wertheim, Denise J. Roe, Sima Ehsani, Sao Jiralerspong, Jennifer Segar, and Pavani Chalasani. 2022. "Feasibility Trial to Evaluate Tendon Stiffness Obtained from Shear Wave Elastography Imaging as a Biomarker of Aromatase Inhibitor-Induced Arthralgias" Journal of Clinical Medicine 11, no. 4: 1067. https://doi.org/10.3390/jcm11041067

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