The Association between Low Levels of Low Density Lipoprotein Cholesterol and Intracerebral Hemorrhage: Cause for Concern?

Gurevitz, Chen; Auriel, Eitan; Elis, Avishay; Kornowski, Ran

doi:10.3390/jcm11030536

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The Association between Low Levels of Low Density Lipoprotein Cholesterol and Intracerebral Hemorrhage: Cause for Concern?

¹

Rabin Medical Center, Department of Cardiology, Beilinson Campus, Petah Tikva 4941492, Israel

²

Rabin Medical Center, Department of Neurology, Beilinson Campus, Petah Tikva 4941492, Israel

³

The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel

⁴

Rabin Medical Center, Department of Internal Medicine C, Beilinson Campus, Petah Tikva 4941492, Israel

^*

Author to whom correspondence should be addressed.

J. Clin. Med. 2022, 11(3), 536; https://doi.org/10.3390/jcm11030536

Submission received: 5 December 2021 / Revised: 27 December 2021 / Accepted: 18 January 2022 / Published: 21 January 2022

(This article belongs to the Collection Current Clinical Treatments and Challenges for Coronary Artery Disease (CAD))

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Abstract

Excessive levels of low-density lipoprotein cholesterol (LDL-C) in the blood are a known risk factor for atherosclerosis, and a common target of treatment for primary and secondary prevention of cerebrocardiovascular disease. As lipid lowering agents including statins, ezetimibe and anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have shown good therapeutic results, the guidelines are constantly lowering the “optimal” LDL-C goals. However, old and new data point towards an association between low LDL-C and total cholesterol and intracerebral hemorrhage (ICH). In this review we aimed to shed light on this troubling association and identify the potential risk factors of such a potential adverse reaction. With respect to the data presented, we concluded that in patients with high risk of ICH, a cautious approach and individualized therapy strategy are advised when considering aggressive LDL reduction.

Keywords: low-density lipoprotein cholesterol; intracerebral hemorrhage; dyslipidemia

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MDPI and ACS Style

Gurevitz, C.; Auriel, E.; Elis, A.; Kornowski, R. The Association between Low Levels of Low Density Lipoprotein Cholesterol and Intracerebral Hemorrhage: Cause for Concern? J. Clin. Med. 2022, 11, 536. https://doi.org/10.3390/jcm11030536

AMA Style

Gurevitz C, Auriel E, Elis A, Kornowski R. The Association between Low Levels of Low Density Lipoprotein Cholesterol and Intracerebral Hemorrhage: Cause for Concern? Journal of Clinical Medicine. 2022; 11(3):536. https://doi.org/10.3390/jcm11030536

Chicago/Turabian Style

Gurevitz, Chen, Eitan Auriel, Avishay Elis, and Ran Kornowski. 2022. "The Association between Low Levels of Low Density Lipoprotein Cholesterol and Intracerebral Hemorrhage: Cause for Concern?" Journal of Clinical Medicine 11, no. 3: 536. https://doi.org/10.3390/jcm11030536

APA Style

Gurevitz, C., Auriel, E., Elis, A., & Kornowski, R. (2022). The Association between Low Levels of Low Density Lipoprotein Cholesterol and Intracerebral Hemorrhage: Cause for Concern? Journal of Clinical Medicine, 11(3), 536. https://doi.org/10.3390/jcm11030536

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The Association between Low Levels of Low Density Lipoprotein Cholesterol and Intracerebral Hemorrhage: Cause for Concern?

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