Exosomes Derived from Non-Classic Sources for Treatment of Post-Traumatic Osteoarthritis and Cartilage Injury of the Knee: In Vivo Review

Li, Dan; Gupta, Puneet; Sgaglione, Nicholas A.; Grande, Daniel A.

doi:10.3390/jcm10092001

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Exosomes Derived from Non-Classic Sources for Treatment of Post-Traumatic Osteoarthritis and Cartilage Injury of the Knee: In Vivo Review

¹

Orthopedic Research Laboratory, The Feinstein Institute for Medical Research, Northwell Health System, Manhasset, NY 11030, USA

²

Department of Orthopaedic Surgery, George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA

³

Department of Orthopaedic Surgery, Long Island Jewish Medical Center, Northwell Health, New Hyde Park, NY 11040, USA

^*

Author to whom correspondence should be addressed.

J. Clin. Med. 2021, 10(9), 2001; https://doi.org/10.3390/jcm10092001

Submission received: 26 February 2021 / Revised: 26 April 2021 / Accepted: 29 April 2021 / Published: 7 May 2021

(This article belongs to the Special Issue Recent Advances in Osteoarthritis Management and Regenerative Strategies)

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Abstract

Osteoarthritis of the knee is one of the most common chronic, debilitating musculoskeletal conditions. Current conservative treatment modalities such as weight loss, non-steroidal anti-inflammatory drugs, and intra-articular steroid injections often only provide temporary pain relief and are unsatisfactory for long-term management. Though end stage osteoarthritis of the knee can be managed with total knee arthroplasty (TKA), finding alternative non-surgical options to delay or prevent the need for TKA are needed due to the increased healthcare costs and expenditures associated with TKA. Exosomes have been of particular interest given recent findings highlighting that stem cells may at least partially mediate some of their effects through the release of extracellular vesicles, such as exosomes. As such, better understanding the biological mechanisms and potential therapeutic effects of these exosomes is necessary. Here, we review in vivo studies that highlight the potential clinical use of exosomes derived from non-classical sources (not bone marrow or adipose derived MSCs derived MSCs) for osteoarthritis of the knee.

Keywords: exosomes; osteoarthritis; cartilage injury; regenerative medicine

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MDPI and ACS Style

Li, D.; Gupta, P.; Sgaglione, N.A.; Grande, D.A. Exosomes Derived from Non-Classic Sources for Treatment of Post-Traumatic Osteoarthritis and Cartilage Injury of the Knee: In Vivo Review. J. Clin. Med. 2021, 10, 2001. https://doi.org/10.3390/jcm10092001

AMA Style

Li D, Gupta P, Sgaglione NA, Grande DA. Exosomes Derived from Non-Classic Sources for Treatment of Post-Traumatic Osteoarthritis and Cartilage Injury of the Knee: In Vivo Review. Journal of Clinical Medicine. 2021; 10(9):2001. https://doi.org/10.3390/jcm10092001

Chicago/Turabian Style

Li, Dan, Puneet Gupta, Nicholas A. Sgaglione, and Daniel A. Grande. 2021. "Exosomes Derived from Non-Classic Sources for Treatment of Post-Traumatic Osteoarthritis and Cartilage Injury of the Knee: In Vivo Review" Journal of Clinical Medicine 10, no. 9: 2001. https://doi.org/10.3390/jcm10092001

APA Style

Li, D., Gupta, P., Sgaglione, N. A., & Grande, D. A. (2021). Exosomes Derived from Non-Classic Sources for Treatment of Post-Traumatic Osteoarthritis and Cartilage Injury of the Knee: In Vivo Review. Journal of Clinical Medicine, 10(9), 2001. https://doi.org/10.3390/jcm10092001

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Exosomes Derived from Non-Classic Sources for Treatment of Post-Traumatic Osteoarthritis and Cartilage Injury of the Knee: In Vivo Review

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