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Article

Intra-Articular Administration of Autologous Purified Adipose Tissue Associated with Arthroscopy Ameliorates Knee Osteoarthritis Symptoms

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87100 Cosenza, Italy
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Author to whom correspondence should be addressed.
Academic Editors: Brunella Grigolo and Giovanna Desando
J. Clin. Med. 2021, 10(10), 2053; https://doi.org/10.3390/jcm10102053
Received: 12 March 2021 / Revised: 20 April 2021 / Accepted: 10 May 2021 / Published: 11 May 2021
The aim of this study was to evaluate the safety and efficacy of the intra-articular administration of autologous purified adipose tissue to treat knee osteoarthritis (OA) following arthroscopy. Thirty patients with radiological evidence of knee OA were recruited. A small liposuction and arthroscopic lavage and debridement were performed in the same surgical time. The harvested fat was processed intraoperatively with Lipocell (Tiss’You, RSM) to purify the adipose tissue injected into the knee. Clinical evaluations were performed with VAS, Womac, and Lequesne questionnaires before treatment and after 1, 3, 6, and 12 months of follow-up. Pain, measured with VAS, significantly decreased, showing a reduction of 53% after 1 month and 83% after a year. Functional recovery, measured with Womac, showed an improvement of 47% after 1 month post-treatment and 84% after 1 year. No adverse effects have been observed. The intra-articular administration of purified adipose tissue associated with arthroscopic lavage and debridement is a safe and significantly effective strategy in improving the symptoms of knee osteoarthritis in up to 1 year of follow-up. View Full-Text
Keywords: osteoarthritis; knee; cartilage; regenerative medicine; adipose tissue; mesenchymal stem cells; Lipocell osteoarthritis; knee; cartilage; regenerative medicine; adipose tissue; mesenchymal stem cells; Lipocell
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MDPI and ACS Style

Caforio, M.; Nobile, C. Intra-Articular Administration of Autologous Purified Adipose Tissue Associated with Arthroscopy Ameliorates Knee Osteoarthritis Symptoms. J. Clin. Med. 2021, 10, 2053. https://doi.org/10.3390/jcm10102053

AMA Style

Caforio M, Nobile C. Intra-Articular Administration of Autologous Purified Adipose Tissue Associated with Arthroscopy Ameliorates Knee Osteoarthritis Symptoms. Journal of Clinical Medicine. 2021; 10(10):2053. https://doi.org/10.3390/jcm10102053

Chicago/Turabian Style

Caforio, Marco, and Carmelo Nobile. 2021. "Intra-Articular Administration of Autologous Purified Adipose Tissue Associated with Arthroscopy Ameliorates Knee Osteoarthritis Symptoms" Journal of Clinical Medicine 10, no. 10: 2053. https://doi.org/10.3390/jcm10102053

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