Next Article in Journal
Cardiovascular Calcification as a Marker of Increased Cardiovascular Risk and a Surrogate for Subclinical Atherosclerosis: Role of Echocardiography
Previous Article in Journal
Comorbidities and Susceptibility to COVID-19: A Generalized Gene Set Data Mining Approach
Article

Prognostic Value of Bioactive Adrenomedullin in Critically Ill Patients with COVID-19 in Germany: An Observational Cohort Study

1
Department of Intensive and Intermediate Care, University Hospital RWTH Aachen, 52074 Aachen, Germany
2
Department of Pneumology and Intensive Care Medicine, University Hospital RWTH Aachen, 52074 Aachen, Germany
3
Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2021, 10(8), 1667; https://doi.org/10.3390/jcm10081667
Received: 17 February 2021 / Revised: 31 March 2021 / Accepted: 6 April 2021 / Published: 13 April 2021
(This article belongs to the Section Intensive Care)
The coronavirus disease 2019 (COVID-19) pandemic has placed a significant burden on hospitals worldwide. Objective biomarkers for early risk stratification and clinical management are still lacking. The aim of this work was to determine whether bioactive adrenomedullin can assist in the risk stratification and clinical management of critically ill COVID-19 patients. Fifty-three patients with confirmed COVID-19 were included in this prospective observational cohort study between March and April 2020. Bioactive adrenomedullin (bio-ADM) plasma concentration was measured daily for seven days after admission. The prognostic value and clinical significance of bio-ADM plasma levels were evaluated for the severity of respiratory failure, the need for extracorporeal organ support and outcome (28-day mortality). Bio-ADM levels increased with the severity of acute respiratory distress syndrome (ARDS; p < 0.001) and were significantly elevated in invasively ventilated patients (p = 0.006) and patients in need of extracorporeal membrane oxygenation (p = 0.040) or renal replacement therapy (RRT; p < 0.001) compared to patients without these conditions. Non-survivors showed significantly higher bio-ADM levels than survivors (p = 0.010). Bio-ADM levels predicted 28-day mortality (C-index 0.72, 95% confidence interval 0.56–0.87, p < 0.001). Bio-ADM plasma levels correlate with disease severity, the need for extracorporeal organ assistance, and outcome, and highlight the promising value of bio-ADM in the early risk stratification and management of patients with COVID-19. View Full-Text
Keywords: ARDS; endothelial dysfunction; bioactive adrenomedullin; biomarker; COVID-19; ECMO ARDS; endothelial dysfunction; bioactive adrenomedullin; biomarker; COVID-19; ECMO
Show Figures

Figure 1

MDPI and ACS Style

Simon, T.-P.; Stoppe, C.; Breuer, T.; Stiehler, L.; Dreher, M.; Kersten, A.; Kluge, S.; Karakas, M.; Zechendorf, E.; Marx, G.; Martin, L. Prognostic Value of Bioactive Adrenomedullin in Critically Ill Patients with COVID-19 in Germany: An Observational Cohort Study. J. Clin. Med. 2021, 10, 1667. https://doi.org/10.3390/jcm10081667

AMA Style

Simon T-P, Stoppe C, Breuer T, Stiehler L, Dreher M, Kersten A, Kluge S, Karakas M, Zechendorf E, Marx G, Martin L. Prognostic Value of Bioactive Adrenomedullin in Critically Ill Patients with COVID-19 in Germany: An Observational Cohort Study. Journal of Clinical Medicine. 2021; 10(8):1667. https://doi.org/10.3390/jcm10081667

Chicago/Turabian Style

Simon, Tim-Philipp, Christian Stoppe, Thomas Breuer, Lara Stiehler, Michael Dreher, Alexander Kersten, Stefan Kluge, Mahir Karakas, Elisabeth Zechendorf, Gernot Marx, and Lukas Martin. 2021. "Prognostic Value of Bioactive Adrenomedullin in Critically Ill Patients with COVID-19 in Germany: An Observational Cohort Study" Journal of Clinical Medicine 10, no. 8: 1667. https://doi.org/10.3390/jcm10081667

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop