Next Article in Journal
Assessing Interventions against Coronavirus Disease 2019 (COVID-19) in Osaka, Japan: A Modeling Study
Next Article in Special Issue
Body Mass Index Reduction and Selected Cardiometabolic Risk Factors in Obstructive Sleep Apnea: Meta-Analysis
Previous Article in Journal
Integrative Biology of Diabetic Retinal Disease: Lessons from Diabetic Kidney Disease
Previous Article in Special Issue
Positive Airway Pressure Therapy Adherence with Mask Resupply: A Propensity-Matched Analysis
 
 
Article

Evaluation of Respiratory Resistance as a Predictor for Oral Appliance Treatment Response in Obstructive Sleep Apnea: A Pilot Study

1
Dental Anesthesiology and Orofacial Pain Management, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8549, Japan
2
Dental Clinic for Sleep Disorders (Apnea and Snoring), Oral and Maxillofacial Rehabilitation, Dental Hospital, Tokyo Medical and Dental University, Tokyo 113-8549, Japan
3
Removable Partial Prosthodontics, Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8549, Japan
4
Department of Respiratory Physiology and Sleep Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8549, Japan
5
Department of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8549, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Yuksel Peker and Nathaniel Watson
J. Clin. Med. 2021, 10(6), 1255; https://doi.org/10.3390/jcm10061255
Received: 13 January 2021 / Revised: 6 March 2021 / Accepted: 16 March 2021 / Published: 18 March 2021
The aim of this study was to determine the utility of respiratory resistance as a predictor of oral appliance (OA) response in obstructive sleep apnea (OSA). Twenty-seven patients with OSA (mean respiratory event index (REI): 17.5 ± 6.5 events/h) were recruited. At baseline, the respiratory resistance (R20) was measured by impulse oscillometry (IOS) with a fitted nasal mask in the supine position, and cephalometric radiographs were obtained to analyze the pharyngeal airway space (SPAS: superior posterior airway space, MAS: middle airway space, IAS: inferior airway space). The R20 and radiographs after the OA treatment were evaluated, and the changes from the baseline were analyzed. A sleep test with OA was carried out using a portable device. The subjects were divided into Responders and Non-responders based on an REI improvement ≥ 50% from the baseline, or REI < 5 after treatment, and the R20 reduction rate between the two groups were compared. The subjects comprised 20 responders and 7 non-responders. The R20 reduction rate with OA in responders was significantly greater than it was in non-responders (14.4 ± 7.9 % versus 2.4 ± 9.8 %, p < 0.05). In responders, SPAS, MAS, and IAS were significantly widened and R20 was significantly decreased with OA (p < 0.05). There was no significant difference in non-responders (p > 0.05). A logistic multiple regression analysis showed that the R20 reduction rate was predictive for OA treatment responses (2% incremental odds ratio (OR), 24.5; 95% CI, 21.5–28.0; p = 0.018). This pilot study confirmed that respiratory resistance may have significant clinical utility in predicting OA treatment responses. View Full-Text
Keywords: obstructive sleep apnea; oral appliance; predictor; respiratory resistance; impulse oscillometry obstructive sleep apnea; oral appliance; predictor; respiratory resistance; impulse oscillometry
Show Figures

Figure 1

MDPI and ACS Style

Ishiyama, H.; Hideshima, M.; Inukai, S.; Tamaoka, M.; Nishiyama, A.; Miyazaki, Y. Evaluation of Respiratory Resistance as a Predictor for Oral Appliance Treatment Response in Obstructive Sleep Apnea: A Pilot Study. J. Clin. Med. 2021, 10, 1255. https://doi.org/10.3390/jcm10061255

AMA Style

Ishiyama H, Hideshima M, Inukai S, Tamaoka M, Nishiyama A, Miyazaki Y. Evaluation of Respiratory Resistance as a Predictor for Oral Appliance Treatment Response in Obstructive Sleep Apnea: A Pilot Study. Journal of Clinical Medicine. 2021; 10(6):1255. https://doi.org/10.3390/jcm10061255

Chicago/Turabian Style

Ishiyama, Hiroyuki, Masayuki Hideshima, Shusuke Inukai, Meiyo Tamaoka, Akira Nishiyama, and Yasunari Miyazaki. 2021. "Evaluation of Respiratory Resistance as a Predictor for Oral Appliance Treatment Response in Obstructive Sleep Apnea: A Pilot Study" Journal of Clinical Medicine 10, no. 6: 1255. https://doi.org/10.3390/jcm10061255

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop