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Article

Prognostic Role of TAPSE to PASP Ratio in Patients Undergoing MitraClip Procedure

1
Cardiology Department, University Hospital of Salamanca, Biomedical Research Institute of Salamanca (IBSAL), 37007 Salamanca, Spain
2
Cardiology Department, Alvaro Cunqueiro University Hospital, 36213 Vigo, Spain
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Cardiology Department, Virgen de la Victoria University Hospital, Biomedical Research Institute of Málaga, 29010 Málaga, Spain
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Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), 28029 Madrid, Spain
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Cardiology Department, University Hospital of Leon, 24071 Leon, Spain
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Cardiology Department, University Hospital Santa Creu i Sant Pau, 08041 Barcelona, Spain
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Cardiology Department, University Hospital Reina Sofia, University of Cordoba and Maimonides Institute for Biomedical Research (IMIBIC), 14004 Córdoba, Spain
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Heart Area, Asturias Central University Hospital, University of Oviedo, Health Research Institute, 33011 Oviedo, Spain
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Cardiovascular Institute, Hospital Clínico San Carlos, Health Research Institute San Carlos (IdISSC), 28040 Madrid, Spain
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Cardiology Department, Clinic University Hospital of Valladolid, Heart Sciences Institute, 47003 Valladolid, Spain
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Cardiology Department, Clínic University Hospital of Barcelona, University of Barcelona, Biomedical Research Institute August Pi i Sunyer (IDIBAPS), 08041 Barcelona, Spain
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Cardiology Department, Ramon y Cajal University Hospital, 28034 Madrid, Spain
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Cardiology Department, Clinical University Hospital of Santiago, 15706 Santiago de Compostela, Spain
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Cardiology Department, University Hospital of Basurto, 48013 Bilbao, Spain
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Cardiology Department, University Hospital of Badajoz, 06080 Badajoz, Spain
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Cardiology Department, General University Hospital of Valencia, 46014 Valencia, Spain
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Cardiology Department, University Clinic Hospital of Valencia, University of Valencia, 46010 Valencia, Spain
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Cardiology Department, University & Polytechnical Hospital La Fe, 46026 Valencia, Spain
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Cardiology Department, University Hospital of Navarra, 31008 Pamplona, Spain
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Cardiology Department, Regional University Hospital of Málaga, 29010 Málaga, Spain
21
Cardiology Department, University of Salamanca, 37008 Salamanca, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Giuseppe Santarpino
J. Clin. Med. 2021, 10(5), 1006; https://doi.org/10.3390/jcm10051006
Received: 13 January 2021 / Revised: 19 February 2021 / Accepted: 23 February 2021 / Published: 2 March 2021
Background: Transcatheter mitral valve repair (TMVR) is an effective therapy for high-risk patients with severe mitral regurgitation (MR) but heart failure (HF) readmissions and death remain substantial on mid-term follow-up. Recently, right ventricular (RV) to pulmonary arterial (PA) coupling has emerged as a relevant prognostic predictor in HF. In this study, we aimed to assess the prognostic value of tricuspid annular plane systolic excursion (TAPSE) to PA systolic pressure (PASP) ratio as a non-invasive measure of RV-to-PA coupling in patients undergoing TMVR with MitraClip (Abbott, CA, USA). Methods: Multicentre registry including 228 consecutive patients that underwent successful TMVR with MitraClip. The sample was divided in two groups according to TAPSE/PASP median value: 0.35. The primary combined endpoint encompassed HF readmissions and all-cause mortality. Results: Mean age was 72.5 ± 11.5 years and 154 (67.5%) patients were male. HF readmissions and all-cause mortality were more frequent in patients with TAPSE/PASP ≤ 0.35: Log-Rank 8.844, p = 0.003. On Cox regression, TAPSE/PASP emerged as a prognostic predictor of the primary combined endpoint, together with STS-Score. TAPSE/PASP was a better prognostic predictor than either TAPSE or PASP separately. Conclusions: TAPSE/PASP ratio appears as a novel prognostic predictor in patients undergoing MitraClip implantation that might improve risk stratification and candidate selection. View Full-Text
Keywords: MitraClip; mitral valve repair; mitral valve regurgitation; pulmonary hypertension; right ventricular to pulmonary arterial coupling; transthoracic echocardiography MitraClip; mitral valve repair; mitral valve regurgitation; pulmonary hypertension; right ventricular to pulmonary arterial coupling; transthoracic echocardiography
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    Doi: 10.5281/zenodo.4436369
    Link: https://zenodo.org/deposit/4436369
    Description: Supplementary Table 1.Supplementary Table 1. Baseline characteristics according to the combined endpoint. Supplementary Table 2. Procedural and 30-day outcomes according to the combined endpoint. Supplementary Table 3. Follow-up TAPSE/PASP ratio determinations after successful transcatheter mitral valve repair.
MDPI and ACS Style

Trejo-Velasco, B.; Estevez-Loureiro, R.; Carrasco-Chinchilla, F.; Fernández-Vázquez, F.; Arzamendi, D.; Pan, M.; Pascual, I.; Nombela-Franco, L.; Amat-Santos, I.J.; Freixa, X.; Hernández-Antolín, R.A.; Trillo-Nouche, R.; Andraka Ikazuriaga, L.; López-Mínguez, J.R.; Sanmiguel Cervera, D.; Sanchis, J.; Diez-Gil, J.L.; Ruiz-Quevedo, V.; Urbano-Carrillo, C.; Becerra-Muñoz, V.M.; Benito-González, T.; Li, C.H.; Mesa, D.; Avanzas, P.; Armijo, G.; Serrador-Frutos, A.M.; Sanchis, L.; Lobán, C.F.-G.; Cid-Álvarez, B.; Hernández-García, J.M.; Garrote-Coloma, C.; Fernández-Peregrina, E.; Romero, M.; León Arguero, V.; Cruz-González, I. Prognostic Role of TAPSE to PASP Ratio in Patients Undergoing MitraClip Procedure. J. Clin. Med. 2021, 10, 1006. https://doi.org/10.3390/jcm10051006

AMA Style

Trejo-Velasco B, Estevez-Loureiro R, Carrasco-Chinchilla F, Fernández-Vázquez F, Arzamendi D, Pan M, Pascual I, Nombela-Franco L, Amat-Santos IJ, Freixa X, Hernández-Antolín RA, Trillo-Nouche R, Andraka Ikazuriaga L, López-Mínguez JR, Sanmiguel Cervera D, Sanchis J, Diez-Gil JL, Ruiz-Quevedo V, Urbano-Carrillo C, Becerra-Muñoz VM, Benito-González T, Li CH, Mesa D, Avanzas P, Armijo G, Serrador-Frutos AM, Sanchis L, Lobán CF-G, Cid-Álvarez B, Hernández-García JM, Garrote-Coloma C, Fernández-Peregrina E, Romero M, León Arguero V, Cruz-González I. Prognostic Role of TAPSE to PASP Ratio in Patients Undergoing MitraClip Procedure. Journal of Clinical Medicine. 2021; 10(5):1006. https://doi.org/10.3390/jcm10051006

Chicago/Turabian Style

Trejo-Velasco, Blanca, Rodrigo Estevez-Loureiro, Fernando Carrasco-Chinchilla, Felipe Fernández-Vázquez, Dabit Arzamendi, Manuel Pan, Isaac Pascual, Luis Nombela-Franco, Ignacio J. Amat-Santos, Xavier Freixa, Rosa A. Hernández-Antolín, Ramiro Trillo-Nouche, Leire Andraka Ikazuriaga, José R. López-Mínguez, Dario Sanmiguel Cervera, Juan Sanchis, José L. Diez-Gil, Valeriano Ruiz-Quevedo, Cristóbal Urbano-Carrillo, Víctor M. Becerra-Muñoz, Tomás Benito-González, Chi H. Li, Dolores Mesa, Pablo Avanzas, Germán Armijo, Ana M. Serrador-Frutos, Laura Sanchis, Covadonga F.-G. Lobán, Belén Cid-Álvarez, José M. Hernández-García, Carmen Garrote-Coloma, Estefanía Fernández-Peregrina, Miguel Romero, Víctor León Arguero, and Ignacio Cruz-González. 2021. "Prognostic Role of TAPSE to PASP Ratio in Patients Undergoing MitraClip Procedure" Journal of Clinical Medicine 10, no. 5: 1006. https://doi.org/10.3390/jcm10051006

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