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Open AccessArticle

Positive Effects of Saliva on Oral Candidiasis: Basic Research on the Analysis of Salivary Properties

Department of Oral Interdisciplinary Medicine, Prosthodontics & Oral Implantology, Graduate School of Dentistry, Kanagawa Dental University, Yokosuka 238-8580, Japan
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Academic Editor: Bruno Chrcanovic
J. Clin. Med. 2021, 10(4), 812; https://doi.org/10.3390/jcm10040812
Received: 25 January 2021 / Revised: 13 February 2021 / Accepted: 16 February 2021 / Published: 17 February 2021
(This article belongs to the Special Issue Metabolomic Analysis in Health and Disease)
The major causes of oral candidiasis include decreased salivary flow rate and the use of ill-fitting dentures. However, the relationships among prosthetic treatment, saliva, and Candida albicans have not been elucidated. This study aimed to examine the effects of prosthetic treatment and changes in saliva (mainly the salivary flow rate) on oral candidiasis symptoms. Participants requiring prosthetic treatment underwent testing for C. albicans, salivary flow rate, intraoral symptoms, and bite force at the initial visit and four months after treatment to evaluate pretreatment and post-treatment changes. The relationships among C. albicans, salivary flow rate, dentures, and intraoral symptoms were analyzed using multiple regression analysis. Denture treatment improved activity against C. albicans as well as the salivary flow rate, intraoral symptoms, and masticatory function. Multiple regression analysis revealed that changes in the stimulated salivary flow rate due to prosthetic treatment significantly improved C. albicans detection (p = 0.011), intraoral symptoms (p = 0.037), and bite force (p = 0.031). This study showed that prosthetic treatment improved salivary flow and intraoral symptoms and confirmed the influence of stimulated salivary flow rate changes. View Full-Text
Keywords: Candida albicans; resting salivary flow rate; stimulated salivary flow rate; prosthodontics; denture Candida albicans; resting salivary flow rate; stimulated salivary flow rate; prosthodontics; denture
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MDPI and ACS Style

Kawanishi, N.; Hoshi, N.; Adachi, T.; Ichigaya, N.; Kimoto, K. Positive Effects of Saliva on Oral Candidiasis: Basic Research on the Analysis of Salivary Properties. J. Clin. Med. 2021, 10, 812. https://doi.org/10.3390/jcm10040812

AMA Style

Kawanishi N, Hoshi N, Adachi T, Ichigaya N, Kimoto K. Positive Effects of Saliva on Oral Candidiasis: Basic Research on the Analysis of Salivary Properties. Journal of Clinical Medicine. 2021; 10(4):812. https://doi.org/10.3390/jcm10040812

Chicago/Turabian Style

Kawanishi, Norishige; Hoshi, Noriyuki; Adachi, Takuya; Ichigaya, Narumi; Kimoto, Katsuhiko. 2021. "Positive Effects of Saliva on Oral Candidiasis: Basic Research on the Analysis of Salivary Properties" J. Clin. Med. 10, no. 4: 812. https://doi.org/10.3390/jcm10040812

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