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Open AccessArticle

Relationship between Standard Uptake Values of Positron Emission Tomography/Computed Tomography and Salivary Metabolites in Oral Cancer: A Pilot Study

1
Department of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan
2
Department of Radiology, Division of Diagnostic Radiology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan
3
Institute for Advanced Biosciences, Keio University, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata 997-0052, Japan
4
Health Promotion and Preemptive Medicine, Research and Development Center for Minimally Invasive Therapies, Tokyo Medical University, Shinjuku, Tokyo 160-8402, Japan
5
Department of Oral and Maxillofacial Radiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita 565-0871, Japan
6
Department of Radiology, Division of Radiation Oncology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(12), 3958; https://doi.org/10.3390/jcm9123958
Received: 12 November 2020 / Revised: 2 December 2020 / Accepted: 3 December 2020 / Published: 7 December 2020
(This article belongs to the Special Issue Metabolomic Analysis in Health and Disease)
18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) is usually used for staging or evaluation of treatment response rather than for cancer screening. However, 18F-FDG PET/CT has also been used in Japan for cancer screening in people with no cancer symptoms, and accumulating evidence supports this application of 18F-FDG PET/CT. Previously, we have observed a correlation between the saliva and tumor metabolomic profiles in patients with oral cancer. Hence, if salivary metabolites demonstrate a significant correlation with PET parameters such as the maximum standardized uptake value (SUVmax), they may have the potential to be used as a screening tool before PET/CT to identify patients with high SUVmax. Hence, in this study, we aimed to explore the relationship between salivary metabolites and SUVmax of 18F-FDG PET/CT using previously collected data. 18F-FDG PET/CT was performed for staging 26 patients with oral cancer. The collected data were integrated and analyzed along with quantified salivary hydrophilic metabolites obtained from the same patients with oral cancer and controls (n = 44). In total, 11 metabolites showed significant correlations with SUVmax in the delayed phases. A multiple logistic regression model of the two metabolites showed the ability to discriminate between patients with oral cancer and controls, with an area under the receiver operating characteristic curve of 0.738 (p = 0.001). This study uniquely confirmed a relationship between salivary metabolites and SUVmax of PET/CT in patients with oral cancer; salivary metabolites were significantly correlated with SUVmax. These salivary metabolites can be used as a screening tool before PET/CT to identify patients with high SUVmax, i.e., to detect the presence of oral cancer. View Full-Text
Keywords: saliva; metabolomics; 18F FDG PET; CT; biomarker saliva; metabolomics; 18F FDG PET; CT; biomarker
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MDPI and ACS Style

Ishikawa, S.; Hiraka, T.; Kirii, K.; Sugimoto, M.; Shimamoto, H.; Sugano, A.; Kitabatake, K.; Toyoguchi, Y.; Kanoto, M.; Nemoto, K.; Soga, T.; Tomita, M.; Iino, M. Relationship between Standard Uptake Values of Positron Emission Tomography/Computed Tomography and Salivary Metabolites in Oral Cancer: A Pilot Study. J. Clin. Med. 2020, 9, 3958. https://doi.org/10.3390/jcm9123958

AMA Style

Ishikawa S, Hiraka T, Kirii K, Sugimoto M, Shimamoto H, Sugano A, Kitabatake K, Toyoguchi Y, Kanoto M, Nemoto K, Soga T, Tomita M, Iino M. Relationship between Standard Uptake Values of Positron Emission Tomography/Computed Tomography and Salivary Metabolites in Oral Cancer: A Pilot Study. Journal of Clinical Medicine. 2020; 9(12):3958. https://doi.org/10.3390/jcm9123958

Chicago/Turabian Style

Ishikawa, Shigeo; Hiraka, Toshitada; Kirii, Kazukuni; Sugimoto, Masahiro; Shimamoto, Hiroaki; Sugano, Ayako; Kitabatake, Kenichiro; Toyoguchi, Yuuki; Kanoto, Masafumi; Nemoto, Kenji; Soga, Tomoyoshi; Tomita, Masaru; Iino, Mitsuyoshi. 2020. "Relationship between Standard Uptake Values of Positron Emission Tomography/Computed Tomography and Salivary Metabolites in Oral Cancer: A Pilot Study" J. Clin. Med. 9, no. 12: 3958. https://doi.org/10.3390/jcm9123958

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