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Article

Inner Retinal Layer Thickness Alterations in Early Age Related Macular Degeneration in Eyes with Subretinal Drusenoid Deposits or Conventional Drusen

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Ophthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, University of Rome Sapienza, St. Andrea Hospital, Via di Grottarossa 1035/1039, 00189 Rome, Italy
2
Department of Ophthalmology, University Hospital Zurich, Frauenklinikstrasse 24, 8091 Zurich, Switzerland
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University of Zurich, Rämistrasse 71, 8006 Zurich, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Yoko Ozawa
J. Clin. Med. 2021, 10(21), 5136; https://doi.org/10.3390/jcm10215136
Received: 24 September 2021 / Revised: 26 October 2021 / Accepted: 29 October 2021 / Published: 31 October 2021
(This article belongs to the Special Issue Clinical Research Advances in Age-Related Macular Degeneration)
The purpose of this study was to evaluate central and parafoveal inner retinal layer thickness in patients with subretinal drusenoid deposits (SDD) or conventional drusen (CD). Participants underwent comprehensive ophthalmoscopic examination. Evidence of SDD or CD was evaluated with near infrared reflectance and spectral domain optical coherence tomography. Quantification of subfoveal lesions was made through a qualitative analysis of vertical and horizontal SD-OCT scans centered on the fovea. Inner retinal layer macular thickness measurements were obtained for central circles with 1, 3, and 5 mm diameter. Continuous variables were compared by the analysis of covariance (ANCOVA) with post-hoc Tukey HSD correction for multiple comparison analysis. Fifty-five patients were included in the study; 18 eyes with SDD alone, 19 eyes with CD alone, and 18 eyes of healthy age-matched subjects. Eight eyes with SDD (44%) and 13 eyes with CD (68%) had subfoveal lesions. There was significant reduction in the inner retinal layer thickness in the central 1mm area and in the superior 3 mm area in the SDD and CD group compared to controls. In conclusion the inner retinal layer is thinner in the central macula and in the superior parafovea in eyes. View Full-Text
Keywords: subretinal drusenoid deposits; reticular pseudodrusen; conventional drusen; age related macular degeneration; inner retina subretinal drusenoid deposits; reticular pseudodrusen; conventional drusen; age related macular degeneration; inner retina
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MDPI and ACS Style

Abdolrahimzadeh, S.; Di Pippo, M.; Sordi, E.; Zweifel, S.A. Inner Retinal Layer Thickness Alterations in Early Age Related Macular Degeneration in Eyes with Subretinal Drusenoid Deposits or Conventional Drusen. J. Clin. Med. 2021, 10, 5136. https://doi.org/10.3390/jcm10215136

AMA Style

Abdolrahimzadeh S, Di Pippo M, Sordi E, Zweifel SA. Inner Retinal Layer Thickness Alterations in Early Age Related Macular Degeneration in Eyes with Subretinal Drusenoid Deposits or Conventional Drusen. Journal of Clinical Medicine. 2021; 10(21):5136. https://doi.org/10.3390/jcm10215136

Chicago/Turabian Style

Abdolrahimzadeh, Solmaz, Mariachiara Di Pippo, Edoardo Sordi, and Sandrine Anne Zweifel. 2021. "Inner Retinal Layer Thickness Alterations in Early Age Related Macular Degeneration in Eyes with Subretinal Drusenoid Deposits or Conventional Drusen" Journal of Clinical Medicine 10, no. 21: 5136. https://doi.org/10.3390/jcm10215136

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