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Review

The Role of CAR-T Cells in Peritoneal Carcinomatosis from Gastric Cancer: Rationale, Experimental Work, and Clinical Applications

by
Siyuan Qian
1,†,
Pedro Villarejo-Campos
1,*,† and
Damián García-Olmo
1,2
1
Department of Surgery, Fundación Jimenez Diaz University Hospital, Avda. Reyes Católicos, 2, 28040 Madrid, Spain
2
Department of Surgery, Universidad Autónoma de Madrid, C/ Arzobispo Morcillo s/n, 28034 Madrid, Spain
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Clin. Med. 2021, 10(21), 5050; https://doi.org/10.3390/jcm10215050
Submission received: 8 October 2021 / Revised: 23 October 2021 / Accepted: 26 October 2021 / Published: 28 October 2021
(This article belongs to the Special Issue Advances in Peritoneal Carcinomatosis from Gastric Cancer)
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Abstract

Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have shown poor effectiveness in treating peritoneal carcinomatosis (PC) of gastric origin with a high tumor burden (high peritoneal cancer index), though there are scarce therapy alternatives that are able to improve survival. In experimental studies, chimeric antigen receptor-T (CAR-T) cell therapy has shown encouraging results in gastric cancer and is currently being evaluated in several clinical trials. Regarding PC, CAR-T cell therapy has also proven useful in experimental studies, especially when administered intraperitoneally, as this route improves cell distribution and lifespan. Although these results need to be supported by ongoing clinical trials, CAR-T cells are a promising new therapeutic approach to peritoneal metastases from gastric cancer. In this review, we summarize the current evidence of the use of CAR-T cells in gastric cancer and PC of gastric origin.
Keywords: gastric adenocarcinoma; peritoneal carcinomatosis; intraperitoneal chemotherapy; cytoreductive surgery; immunotherapy; cell therapy gastric adenocarcinoma; peritoneal carcinomatosis; intraperitoneal chemotherapy; cytoreductive surgery; immunotherapy; cell therapy

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MDPI and ACS Style

Qian, S.; Villarejo-Campos, P.; García-Olmo, D. The Role of CAR-T Cells in Peritoneal Carcinomatosis from Gastric Cancer: Rationale, Experimental Work, and Clinical Applications. J. Clin. Med. 2021, 10, 5050. https://doi.org/10.3390/jcm10215050

AMA Style

Qian S, Villarejo-Campos P, García-Olmo D. The Role of CAR-T Cells in Peritoneal Carcinomatosis from Gastric Cancer: Rationale, Experimental Work, and Clinical Applications. Journal of Clinical Medicine. 2021; 10(21):5050. https://doi.org/10.3390/jcm10215050

Chicago/Turabian Style

Qian, Siyuan, Pedro Villarejo-Campos, and Damián García-Olmo. 2021. "The Role of CAR-T Cells in Peritoneal Carcinomatosis from Gastric Cancer: Rationale, Experimental Work, and Clinical Applications" Journal of Clinical Medicine 10, no. 21: 5050. https://doi.org/10.3390/jcm10215050

APA Style

Qian, S., Villarejo-Campos, P., & García-Olmo, D. (2021). The Role of CAR-T Cells in Peritoneal Carcinomatosis from Gastric Cancer: Rationale, Experimental Work, and Clinical Applications. Journal of Clinical Medicine, 10(21), 5050. https://doi.org/10.3390/jcm10215050

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