Next Article in Journal
Adverse Events during Vitrectomy under Adequacy of Anesthesia—An Additional Report
Next Article in Special Issue
Reduced Parasympathetic Reactivation during Recovery from Exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Previous Article in Journal
Parental Distress and Perception of Children’s Executive Functioning after the First COVID-19 Lockdown in Italy
Previous Article in Special Issue
Effects of Non-Pharmacological Treatment on Pain, Flexibility, Balance and Quality of Life in Women with Fibromyalgia: A Randomised Clinical Trial
 
 
Article

Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping

1
ME/CFS Research Unit, Division of Rheumatology, Vall d’Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain
2
Departamento de Ciencias Básicas y Transversales, Facultad de Veterinaria y Ciencias Experimentales, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain
3
Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain
4
ME/CFS Clinical Unit, Division of Rheumatology, Vall d’Hebron University Hospital, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain
5
Department of Pathology, School of Health Sciences, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain
*
Authors to whom correspondence should be addressed.
Academic Editors: Giovanni Ricevuti and Lorenzo Lorusso
J. Clin. Med. 2021, 10(18), 4171; https://doi.org/10.3390/jcm10184171
Received: 27 August 2021 / Revised: 10 September 2021 / Accepted: 13 September 2021 / Published: 15 September 2021
Background: Routine blood analytics are systematically used in the clinic to diagnose disease or confirm individuals’ healthy status. For myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a disease relying exclusively on clinical symptoms for its diagnosis, blood analytics only serve to rule out underlying conditions leading to exerting fatigue. However, studies evaluating complete and large blood datasets by combinatorial approaches to evidence ME/CFS condition or detect/identify case subgroups are still scarce. Methods: This study used unbiased hierarchical cluster analysis of a large cohort of 250 carefully phenotyped female ME/CFS cases toward exploring this possibility. Results: The results show three symptom-based clusters, classified as severe, moderate, and mild, presenting significant differences (p < 0.05) in five blood parameters. Unexpectedly the study also revealed high levels of circulating complement factor C1q in 107/250 (43%) of the participants, placing C1q as a key molecule to identify an ME/CFS subtype/subgroup with more apparent pain symptoms. Conclusions: The results obtained have important implications for the research of ME/CFS etiology and, most likely, for the implementation of future diagnosis methods and treatments of ME/CFS in the clinic. View Full-Text
Keywords: myalgic encephalomyelitis; chronic fatigue syndrome; C1q; complement system; blood analytics; diagnosis; symptoms; cluster analysis myalgic encephalomyelitis; chronic fatigue syndrome; C1q; complement system; blood analytics; diagnosis; symptoms; cluster analysis
Show Figures

Figure 1

MDPI and ACS Style

Castro-Marrero, J.; Zacares, M.; Almenar-Pérez, E.; Alegre-Martín, J.; Oltra, E. Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping. J. Clin. Med. 2021, 10, 4171. https://doi.org/10.3390/jcm10184171

AMA Style

Castro-Marrero J, Zacares M, Almenar-Pérez E, Alegre-Martín J, Oltra E. Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping. Journal of Clinical Medicine. 2021; 10(18):4171. https://doi.org/10.3390/jcm10184171

Chicago/Turabian Style

Castro-Marrero, Jesús, Mario Zacares, Eloy Almenar-Pérez, José Alegre-Martín, and Elisa Oltra. 2021. "Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping" Journal of Clinical Medicine 10, no. 18: 4171. https://doi.org/10.3390/jcm10184171

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop