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Article

Pattern of Prostate Cancer Recurrence Assessed by 68Ga-PSMA-11 PET/CT in Men Treated with Primary Local Therapy

1
Department of Nuclear Medicine, University of Pretoria, Pretoria 0001, South Africa
2
Nuclear Medicine Research Infrastructure (NuMeRI), Steve Biko Academic Hospital, Pretoria 0001, South Africa
3
Department of Epidemiology and Community Health, University of Ilorin, Ilorin 240102, Nigeria
4
Department of Nuclear Medicine, University of Ibadan, Ibadan 200284, Nigeria
*
Author to whom correspondence should be addressed.
Academic Editors: Emmanuel Andrès and Fred Saad
J. Clin. Med. 2021, 10(17), 3883; https://doi.org/10.3390/jcm10173883
Received: 28 June 2021 / Revised: 3 August 2021 / Accepted: 10 August 2021 / Published: 29 August 2021
(This article belongs to the Special Issue Recent Advances in Prostate Cancer Treatment)
Imaging plays a vital role in detecting the recurrence of prostate cancer (PCa) to guide the choice of salvage therapy. Gallium-68 prostate-specific membrane antigen positron-emission tomography/computed tomography (68Ga-PSMA-11 PET/CT) is useful for detecting PCa recurrence. We assessed the pattern of PCa recurrence stratified by serum prostate-specific antigen level and type of primary local treatment in men with biochemical recurrence (BCR) after primary local therapy with radical prostatectomy or external beam radiotherapy (EBRT) using 68Ga-PSMA-11 PET/CT. We reviewed patients imaged with 68Ga-PSMA-11 PET/CT for the localization of the site of PCa recurrence. We determined the site and number of lesions due to PCa recurrence at different PSA levels. A total of 247 men (mean age of 65.72 ± 7.51 years and median PSA of 2.70 ng/mL (IQR = 0.78–5.80)) were included. 68Ga-PSMA-11 PET/CT detected the site of recurrence in 81.4% of patients with a median number of lesions per patient of 1 (range = 1–5). 68Ga-PSMA-11 PET/CT positivity was 43.6%, 75.7%, 83.3%, 90.0%, and 95.8% at PSA levels of <0.5, 0.5–1.0., 1.1–2.0, 2.1–5.0, and 5.0–10.0, respectively. The most common site of recurrence was in the prostate gland/bed at all PSA levels. Pelvic, extra-pelvic, and combined pelvic and extra-pelvic sites of recurrence were seen in 118, 50, and 33 patients, respectively. The risk of extra-pelvic recurrence increases with rising PSA levels. 68Ga-PSMA-11 PET/CT has a high lesion detection rate for biochemical recurrence of PCa in patients previously treated with primary local therapy. View Full-Text
Keywords: prostate cancer; radical prostatectomy; radiotherapy; biochemical recurrence; PSMA; PET/CT; PSA prostate cancer; radical prostatectomy; radiotherapy; biochemical recurrence; PSMA; PET/CT; PSA
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MDPI and ACS Style

Lawal, I.O.; Lengana, T.; Popoola, G.O.; Orunmuyi, A.T.; Kgatle, M.M.; Mokoala, K.M.G.; Sathekge, M.M. Pattern of Prostate Cancer Recurrence Assessed by 68Ga-PSMA-11 PET/CT in Men Treated with Primary Local Therapy. J. Clin. Med. 2021, 10, 3883. https://doi.org/10.3390/jcm10173883

AMA Style

Lawal IO, Lengana T, Popoola GO, Orunmuyi AT, Kgatle MM, Mokoala KMG, Sathekge MM. Pattern of Prostate Cancer Recurrence Assessed by 68Ga-PSMA-11 PET/CT in Men Treated with Primary Local Therapy. Journal of Clinical Medicine. 2021; 10(17):3883. https://doi.org/10.3390/jcm10173883

Chicago/Turabian Style

Lawal, Ismaheel O., Thabo Lengana, Gbenga O. Popoola, Akintunde T. Orunmuyi, Mankgopo M. Kgatle, Kgomotso M.G. Mokoala, and Mike M. Sathekge. 2021. "Pattern of Prostate Cancer Recurrence Assessed by 68Ga-PSMA-11 PET/CT in Men Treated with Primary Local Therapy" Journal of Clinical Medicine 10, no. 17: 3883. https://doi.org/10.3390/jcm10173883

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