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Article

Comparison of Non-Tumoral Portal Vein Thrombosis Management in Cirrhotic Patients: TIPS Versus Anticoagulation Versus No Treatment

1
Division of Vascular Interventional Radiology, Department of Radiology, NYU Grossman School of Medicine, New York, NY 10016, USA
2
Division of Abdominal Imaging, Department of Radiology, NYU Grossman School of Medicine, New York, NY 10016, USA
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Department of Population Health, NYU Grossman School of Medicine, New York, NY 10016, USA
4
Hepatology Section, Division of Gastroenterology, Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA
5
Transplant Institute, Department of Surgery, NYU Grossman School of Medicine, New York, NY 10016, USA
6
Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Olivier Morel
J. Clin. Med. 2021, 10(11), 2316; https://doi.org/10.3390/jcm10112316
Received: 13 April 2021 / Revised: 21 April 2021 / Accepted: 11 May 2021 / Published: 26 May 2021
(This article belongs to the Section Nuclear Medicine & Radiology)
Background: There is a lack of consensus in optimal management of portal vein thrombosis (PVT) in patients with cirrhosis. The purpose of this study is to compare the safety and thrombosis burden change for cirrhotic patients with non-tumoral PVT managed by transjugular intrahepatic portosystemic shunt (TIPS) only, anticoagulation only, or no treatment. Methods: This single-center retrospective study evaluated 52 patients with cirrhosis and non-tumoral PVT managed by TIPS only (14), anticoagulation only (11), or no treatment (27). The demographic, clinical, and imaging data for patients were collected. The portomesenteric thrombosis burden and liver function tests at early follow-up (6–9 months) and late follow-up (9–16 months) were compared to the baseline. Adverse events including bleeding and encephalopathy were recorded. Results: The overall portomesenteric thrombosis burden improved in eight (72%) TIPS patients, three (27%) anticoagulated patients, and two (10%) untreated patients at early follow-up (p = 0.001) and in seven (78%) TIPS patients, two (29%) anticoagulated patients, and three (17%) untreated patients in late follow-up (p = 0.007). No bleeding complications attributable to anticoagulation were observed. Conclusion: TIPS decreased portomesenteric thrombus burden compared to anticoagulation or no treatment for cirrhotic patients with PVT. Both TIPS and anticoagulation were safe therapies. View Full-Text
Keywords: non-tumoral portal vein thrombosis; transjugular intrahepatic portosystemic shunt; anticoagulation non-tumoral portal vein thrombosis; transjugular intrahepatic portosystemic shunt; anticoagulation
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MDPI and ACS Style

Zhan, C.; Prabhu, V.; Kang, S.K.; Li, C.; Zhu, Y.; Kim, S.; Olsen, S.; Jacobson, I.M.; Dagher, N.N.; Carney, B.; Hickey, R.M.; Taslakian, B. Comparison of Non-Tumoral Portal Vein Thrombosis Management in Cirrhotic Patients: TIPS Versus Anticoagulation Versus No Treatment. J. Clin. Med. 2021, 10, 2316. https://doi.org/10.3390/jcm10112316

AMA Style

Zhan C, Prabhu V, Kang SK, Li C, Zhu Y, Kim S, Olsen S, Jacobson IM, Dagher NN, Carney B, Hickey RM, Taslakian B. Comparison of Non-Tumoral Portal Vein Thrombosis Management in Cirrhotic Patients: TIPS Versus Anticoagulation Versus No Treatment. Journal of Clinical Medicine. 2021; 10(11):2316. https://doi.org/10.3390/jcm10112316

Chicago/Turabian Style

Zhan, Chenyang, Vinay Prabhu, Stella K. Kang, Clayton Li, Yuli Zhu, Sooah Kim, Sonja Olsen, Ira M. Jacobson, Nabil N. Dagher, Brendan Carney, Ryan M. Hickey, and Bedros Taslakian. 2021. "Comparison of Non-Tumoral Portal Vein Thrombosis Management in Cirrhotic Patients: TIPS Versus Anticoagulation Versus No Treatment" Journal of Clinical Medicine 10, no. 11: 2316. https://doi.org/10.3390/jcm10112316

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