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Auxiliary Subunits: Shepherding AMPA Receptors to the Plasma Membrane

1
Department of Biochemistry I—Receptor Biochemistry, Ruhr University Bochum, Universitätsstraße 150, 44780 Bochum, Germany
2
Graduate School of Chemistry and Biochemistry, Ruhr University Bochum, Universitätsstraße 150, 44780 Bochum, Germany
3
Ruhr University Bochum Research School Plus, Ruhr University Bochum, Universitätsstraße 150, 44780 Bochum, Germany
4
International Graduate School of Neuroscience, Ruhr University Bochum, Universitätsstrraße 150, 44780 Bochum, Germany
*
Author to whom correspondence should be addressed.
Membranes 2014, 4(3), 469-490; https://doi.org/10.3390/membranes4030469
Received: 16 June 2014 / Revised: 17 July 2014 / Accepted: 25 July 2014 / Published: 8 August 2014
(This article belongs to the Special Issue Trafficking of Membrane Receptors)
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated cation channels that mediate excitatory signal transmission in the central nervous system (CNS) of vertebrates. The members of the iGluR subfamily of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors (AMPARs) mediate most of the fast excitatory signal transmission, and their abundance in the postsynaptic membrane is a major determinant of the strength of excitatory synapses. Therefore, regulation of AMPAR trafficking to the postsynaptic membrane is an important constituent of mechanisms involved in learning and memory formation, such as long-term potentiation (LTP) and long-term depression (LTD). Auxiliary subunits play a critical role in the facilitation and regulation of AMPAR trafficking and function. The currently identified auxiliary subunits of AMPARs are transmembrane AMPA receptor regulatory proteins (TARPs), suppressor of lurcher (SOL), cornichon homologues (CNIHs), synapse differentiation-induced gene I (SynDIG I), cysteine-knot AMPAR modulating proteins 44 (CKAMP44), and germ cell-specific gene 1-like (GSG1L) protein. In this review we summarize our current knowledge of the modulatory influence exerted by these important but still underappreciated proteins. View Full-Text
Keywords: AMPA; glutamate receptor; trafficking; auxiliary subunit; TARP; cornichon homologue; CNIH; shisa; SynDIG; CKAMP; GSG1L AMPA; glutamate receptor; trafficking; auxiliary subunit; TARP; cornichon homologue; CNIH; shisa; SynDIG; CKAMP; GSG1L
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Haering, S.C.; Tapken, D.; Pahl, S.; Hollmann, M. Auxiliary Subunits: Shepherding AMPA Receptors to the Plasma Membrane. Membranes 2014, 4, 469-490.

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