Harnessing T-Cells for Enhanced Vaccine Development against Viral Infections

Zhuang, Zhen; Zhuo, Jianfen; Yuan, Yaochang; Chen, Zhao; Zhang, Shengnan; Zhu, Airu; Zhao, Jingxian; Zhao, Jincun

doi:10.3390/vaccines12050478

Open AccessReview

Harnessing T-Cells for Enhanced Vaccine Development against Viral Infections

by

Zhen Zhuang

^1,†,

Jianfen Zhuo

^1,2,†,

Yaochang Yuan

¹,

Zhao Chen

¹,

Shengnan Zhang

¹,

Airu Zhu

¹,

Jingxian Zhao

^1,2 and

Jincun Zhao

^1,2,*

¹

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China

²

Guangzhou National Laboratory, Guangzhou 510005, China

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Vaccines 2024, 12(5), 478; https://doi.org/10.3390/vaccines12050478

Submission received: 27 March 2024 / Revised: 25 April 2024 / Accepted: 28 April 2024 / Published: 29 April 2024

(This article belongs to the Special Issue Review Special Issue Series: T-cell Based Vaccine Development against Pathogen Infections)

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Abstract

Despite significant strides in vaccine research and the availability of vaccines for many infectious diseases, the threat posed by both known and emerging infectious diseases persists. Moreover, breakthrough infections following vaccination remain a concern. Therefore, the development of novel vaccines is imperative. These vaccines must exhibit robust protective efficacy, broad-spectrum coverage, and long-lasting immunity. One promising avenue in vaccine development lies in leveraging T-cells, which play a crucial role in adaptive immunity and regulate immune responses during viral infections. T-cell recognition can target highly variable or conserved viral proteins, and memory T-cells offer the potential for durable immunity. Consequently, T-cell-based vaccines hold promise for advancing vaccine development efforts. This review delves into the latest research advancements in T-cell-based vaccines across various platforms and discusses the associated challenges.

Keywords: vaccine; T-cell epitope; T-cell-based vaccine; viral infection

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MDPI and ACS Style

Zhuang, Z.; Zhuo, J.; Yuan, Y.; Chen, Z.; Zhang, S.; Zhu, A.; Zhao, J.; Zhao, J. Harnessing T-Cells for Enhanced Vaccine Development against Viral Infections. Vaccines 2024, 12, 478. https://doi.org/10.3390/vaccines12050478

AMA Style

Zhuang Z, Zhuo J, Yuan Y, Chen Z, Zhang S, Zhu A, Zhao J, Zhao J. Harnessing T-Cells for Enhanced Vaccine Development against Viral Infections. Vaccines. 2024; 12(5):478. https://doi.org/10.3390/vaccines12050478

Chicago/Turabian Style

Zhuang, Zhen, Jianfen Zhuo, Yaochang Yuan, Zhao Chen, Shengnan Zhang, Airu Zhu, Jingxian Zhao, and Jincun Zhao. 2024. "Harnessing T-Cells for Enhanced Vaccine Development against Viral Infections" Vaccines 12, no. 5: 478. https://doi.org/10.3390/vaccines12050478

APA Style

Zhuang, Z., Zhuo, J., Yuan, Y., Chen, Z., Zhang, S., Zhu, A., Zhao, J., & Zhao, J. (2024). Harnessing T-Cells for Enhanced Vaccine Development against Viral Infections. Vaccines, 12(5), 478. https://doi.org/10.3390/vaccines12050478

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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