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COVID-19 Vaccination in China: Adverse Effects and Its Impact on Health Care Working Decisions on Booster Dose

1
Evidence-Based Medicine Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai 317000, China
2
Department of Orthopedics, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai 317000, China
*
Author to whom correspondence should be addressed.
Academic Editors: Alessandra Casuccio and Giuseppe La Torre
Vaccines 2022, 10(8), 1229; https://doi.org/10.3390/vaccines10081229
Received: 6 May 2022 / Revised: 16 June 2022 / Accepted: 22 June 2022 / Published: 31 July 2022
(This article belongs to the Section COVID-19 Vaccines and Vaccination)
Although many research studies have concentrated on people’s willingness to take the COVID-19 vaccine, little attention has been paid to the underlying mechanism of consent. An understanding of potential factors and mechanisms that affect the willingness to receive a vaccination can contribute information critical for containing the pandemic. This study explored the effects of post-vaccination adverse reactions on the willingness to take the booster dose and the role of decision regret. A self-administered online survey was carried out in Taizhou, China. Questionnaires were completed by 1085 healthcare workers (HCWs), 1054 (97.1%) of whom had completed two doses of the COVID-19 vaccine. Mediation analysis methodology was applied in this study. Our study showed that post-vaccination adverse reactions in HCWs could decrease their willingness to take the booster dose. Of note, HCWs who experienced adverse reactions after vaccination would be more likely to regret their previous vaccination decisions, which, in turn, further reduced their willingness to receive a booster shot. Decision regret mediated the relationship between adverse post-vaccination reactions and a willingness to take the booster dose. The findings implied inextricable relationships among post-vaccination adverse reactions, decision regret, and willingness to take the booster dose. It is suggested that notice of these post-vaccination adverse reactions should be further incorporated into vaccine communication campaigns and policy interventions advocating booster doses to improve vaccine uptake intent and increase the willingness to receive booster doses of a COVID-19 vaccine. View Full-Text
Keywords: healthcare workers; willingness; vaccination adverse reaction; decision regret; COVID-19 booster vaccine healthcare workers; willingness; vaccination adverse reaction; decision regret; COVID-19 booster vaccine
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MDPI and ACS Style

Luo, C.; Chen, H.-X.; Tung, T.-H. COVID-19 Vaccination in China: Adverse Effects and Its Impact on Health Care Working Decisions on Booster Dose. Vaccines 2022, 10, 1229. https://doi.org/10.3390/vaccines10081229

AMA Style

Luo C, Chen H-X, Tung T-H. COVID-19 Vaccination in China: Adverse Effects and Its Impact on Health Care Working Decisions on Booster Dose. Vaccines. 2022; 10(8):1229. https://doi.org/10.3390/vaccines10081229

Chicago/Turabian Style

Luo, Chengwen, Hai-Xiao Chen, and Tao-Hsin Tung. 2022. "COVID-19 Vaccination in China: Adverse Effects and Its Impact on Health Care Working Decisions on Booster Dose" Vaccines 10, no. 8: 1229. https://doi.org/10.3390/vaccines10081229

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