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Vaccines
Volume 10
Issue 5
10.3390/vaccines10050741
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Article

Anti-SARS-CoV-2S Antibody Levels in Healthcare Workers 10 Months after the Administration of Two BNT162b2 Vaccine Doses in View of Demographic Characteristic and Previous COVID-19 Infection

by
Blanka Wolszczak-Biedrzycka
1,2,*,
Anna Bieńkowska
1,2,
Joanna Ewa Zaborowska
3,
Elwira Smolińska-Fijołek
4,
Grzegorz Biedrzycki
5 and
Justyna Dorf
6
1
Department of Psychology and Sociology of Health and Public Health, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland
2
The Oncology Center of the Region of Warmia and Mazury in Olsztyn, Hospital of the Ministry of the Interior and Administration, 10-228 Olsztyn, Poland
3
District Hospital in Bartoszyce, 11-200 Bartoszyce, Poland
4
Department of Physiology, Medical University in Gdańsk, 80-211 Gdańsk, Poland
5
Hospital Dispensary, Regional Specialist Hospital in Olsztyn, 10-561 Olsztyn, Poland
6
Department of Clinical Laboratory Diagnostics, Medical University of Białystok, Waszyngtona 15A, 15-269 Bialystok, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: S. Louise Cosby
Vaccines 2022, 10(5), 741; https://doi.org/10.3390/vaccines10050741
Received: 7 February 2022 / Revised: 16 April 2022 / Accepted: 6 May 2022 / Published: 9 May 2022
(This article belongs to the Special Issue The COVID Vaccine)
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Abstract

Antibody levels that confer full protection against SARS-CoV-2 infection after the administration of different vaccine brands as well as the factors influencing the humoral immune response have been analyzed extensively ever since the vaccination program was launched in late 2020. The aim of this study was to determine anti-SARS-CoV-2S antibody titers in 100 healthcare workers 10 months after the administration of two BNT162b2 vaccine doses, and to investigate the influence of demographic characteristics, the presence of comorbidities and history of COVID-19 infection. The results were compared with antibody levels that were determined eight months after the administration of two BNT162b2 vaccine doses in our previous study. Antibody levels in venous blood serum were measured by the ECLIA method with the use of the Roche Cobas e411 analyzer. In all tested subjects, antibody titers remained high 10 months after vaccination, particularly in recovered COVID-19 patients, and only a minor decrease was observed relative to the values noted two months earlier. View Full-Text
Keywords: BNT162b2; anti-SARS-CoV-2 antibodies; COVID-19; healthcare workers BNT162b2; anti-SARS-CoV-2 antibodies; COVID-19; healthcare workers
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MDPI and ACS Style

Wolszczak-Biedrzycka, B.; Bieńkowska, A.; Zaborowska, J.E.; Smolińska-Fijołek, E.; Biedrzycki, G.; Dorf, J. Anti-SARS-CoV-2S Antibody Levels in Healthcare Workers 10 Months after the Administration of Two BNT162b2 Vaccine Doses in View of Demographic Characteristic and Previous COVID-19 Infection. Vaccines 2022, 10, 741. https://doi.org/10.3390/vaccines10050741

AMA Style

Wolszczak-Biedrzycka B, Bieńkowska A, Zaborowska JE, Smolińska-Fijołek E, Biedrzycki G, Dorf J. Anti-SARS-CoV-2S Antibody Levels in Healthcare Workers 10 Months after the Administration of Two BNT162b2 Vaccine Doses in View of Demographic Characteristic and Previous COVID-19 Infection. Vaccines. 2022; 10(5):741. https://doi.org/10.3390/vaccines10050741

Chicago/Turabian Style

Wolszczak-Biedrzycka, Blanka, Anna Bieńkowska, Joanna E. Zaborowska, Elwira Smolińska-Fijołek, Grzegorz Biedrzycki, and Justyna Dorf. 2022. "Anti-SARS-CoV-2S Antibody Levels in Healthcare Workers 10 Months after the Administration of Two BNT162b2 Vaccine Doses in View of Demographic Characteristic and Previous COVID-19 Infection" Vaccines 10, no. 5: 741. https://doi.org/10.3390/vaccines10050741

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